There is an urgent need for the development of human-like tumor
models. Researchers have used tissue engineering to create models for
studying the bone-destroying activity of tumors such as the aggressive
pediatric cancer Ewing's sarcoma.
A new 3-dimensional, living model of
the osteolytic process and bone remodeling, which can serve a valuable
tool for exploring disease mechanisms and the effectiveness of potential
treatments, is described in Tissue Engineering
, Part C, Methods, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.
‘Using tissue engineering researchers have created models for studying the bone-destroying activity of tumors such as the aggressive pediatric cancer Ewing's sarcoma.’
In the article entitled "Tissue-Engineered Model of Human Osteolytic
Bone Tumor," Gordana Vunjak-Novakovic and coauthors from Columbia
University, New York, NY and Politecnico di Milano, Italy, present the
methods used to bioengineer a living Ewing's sarcoma model that includes
both osteoclasts and osteoblasts in a controllable biomimetic
environment. The researchers demonstrate the usefulness of the model for
testing anti-osteolytic drugs.
"This article is an excellent example of the progress being
made," says Methods Co-Editor-in-Chief John A. Jansen, Professor and Head, Department of Biomaterials, Radboud University
Medical Center, The Netherlands.