There is an urgent need for the development of human-like tumor
models. Researchers have used tissue engineering to create models for
studying the bone-destroying activity of tumors such as the aggressive
pediatric cancer Ewing's sarcoma.
A new 3-dimensional, living model of the osteolytic process and bone remodeling, which can serve a valuable tool for exploring disease mechanisms and the effectiveness of potential treatments, is described in Tissue Engineering, Part C, Methods, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.
In the article entitled "Tissue-Engineered Model of Human Osteolytic Bone Tumor," Gordana Vunjak-Novakovic and coauthors from Columbia University, New York, NY and Politecnico di Milano, Italy, present the methods used to bioengineer a living Ewing's sarcoma model that includes both osteoclasts and osteoblasts in a controllable biomimetic environment. The researchers demonstrate the usefulness of the model for testing anti-osteolytic drugs.