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Promising Target for Treating Duchenne Muscular Dystrophy Discovered

by Sheela Philomena on September 13, 2016 at 10:43 AM
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Promising Target for Treating Duchenne Muscular Dystrophy Discovered

Research team have discovered a new protein target that may slow the progression in Duchenne muscular dystrophy.

Duchenne muscular dystrophy is a chronic disease causing severe muscle degeneration that is ultimately fatal. As the disease progresses, muscle precursor cells lose the ability to create new musclar tissue, leading to faster muscle deterioration. 

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This month in the JCI, work led by Ming-Jer Tsai at Baylor College of Medicine has identified a protein involved in coordinating the function of muscle precursor cells.

In a mouse model of Duchenne muscular dystrophy, abnormally high levels of COUP-TFII exacerbated symptoms of muscle deterioration and diminished recovery after muscle injuries. 
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These symptoms were linked to decreases in muscle precursor cell function. In contrast, reducing COUP-TFII activity decreased muscle degeneration in the mouse model. 

These results indicate that blocking COUP-TFII may have beneficial therapeutic effects for delaying the progression of Duchenne muscular dystrophy.

Source: Eurekalert
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