About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Promising New Treatment for Allergic Contact Dermatitis

by Anjali Aryamvally on March 10, 2018 at 7:38 PM
Font : A-A+

Promising New Treatment for Allergic Contact Dermatitis

A promising new treatment for allergic contact dermatitis was discovered by a research team led by Nicolas Bazan, MD, PhD, Boyd Professor and Director of the Neuroscience Center of Excellence at LSU Health New Orleans School of Medicine. The new treatment published in Dermatology and Therapy offers an alternative to corticosteroids and their possible side effects.

Working in an experimental model of allergic contact dermatitis, the research team developed a mixture of antioxidants and moisturizers, combined with potent free radical scavengers and inhibitors, which suppressed an inflammatory response to the irritant. The cream relieved itch, reduced swelling and protected peripheral nerves in the affected area.

Advertisement


Allergic contact dermatitis (ACD) is caused by exposure to an allergen in sensitive people. Sensitizing allergens include nickel and gold, perfumes, soaps or organic compounds. Although removal of the allergen reduces symptoms, recovery can take weeks. The authors also note that allergic contact dermatitis represents 5-10% of doctor visits.

One of the current primary treatments for severe allergic contact dermatitis is the use of corticosteroids. Long-term use of corticosteroids can result in skin atrophy, spider veins, loss of skin color or corticosteroid acne. They can disrupt the skin's barrier and lead to adrenal suppression, altered growth, hypertension, hyperglycemia, insulin resistance and cataracts, and they may increase the risk for certain cancers.
Advertisement

The experimental cream, on the other hand, successfully treated allergic contact dermatitis in mice, without the side effects of corticosteroids. The new cream works in a different way by preventing or stopping the process that initiates inflammation.

This project is part of a long collaboration that Dr. Bazan developed with Dr. Ricardo Palacios-Pelaez from Spain on inflammation, immunity and neurodegenerative diseases.

"Now with the new cream, we targeted some of those mechanisms in a relatively less complex condition in the skin, always with translational-enabling goals," said Bazan.

Other members of the research team included Drs. William Gordon, Surjyadipta Bhattacharjee and Bokkyoo Jun at LSU Health New Orleans Neuroscience Center of Excellence, as well as Drs. Virginia Garciá López, David Rodríguez Gil, Javier Alcover Díaz, Fernando Pineda de la Losa, Ricardo Palacios Peláez, Concha Tiana Ferrer and Gabriela Silvina Bacchini from Madrid, Spain; along with Hélène Varoqui at Ochsner.

"While our results are very promising, additional studies are needed to determine the ideal duration of treatment and the most efficacious concentrations of the active components in the test formulations that will best alleviate ACD," Bazan concluded.

The research was supported by a grant from the National Institute of General Medical Sciences, as well as LSU Health New Orleans Neuroscience Center of Excellence.

This work is part of Bazan's innovative research searching for novel fundamental principles of tissue/organ injury involving inflammation, immunology, genetics and epigenetics. Most of his efforts are focused on responses to damage to the brain and retina and include Parkinson's, Alzheimer's, pain, Macular degeneration and traumatic brain injury, but as these findings demonstrate, fundamental discoveries have broad application.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
First-Ever Successful Pig-To-Human Kidney Transplantation
World Osteoporosis Day 2021 -
Spirituality and Mental Health
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Allergy Atopic Dermatitis Scleroderma Dealing with Pollen Allergy Foods that are Bad for your Skin Itchy Armpits Eczema: Miracles with Homeopathy Dermatitis Contact Dermatitis 

Recommended Reading
Mobile Phones Could Cause Allergic Contact Dermatitis
Nickel and chromium in mobile phones are sufficient to induce allergic contact dermatitis (ACD), ......
Key Driver of Atopic Dermatitis Discovered
A crucial member that plays a major role in promoting skin inflammation in atopic dermatitis has ......
Low Vitamin D Levels May Not Increase Risk of Asthma, Dermatitis
Genetic alterations that are associated with vitamin D levels do not predispose people to asthma, .....
Pediatric Atopic Dermatitis Associated With Increased Lymphocyte Activation
Early immune intervention at a young age treat the eczema and prevent other allergic diseases which ...
Allergy
An allergy is a hypersensitive disorder of immune system. Substances that often cause allergic react...
Atopic Dermatitis
Atopic dermatitis is an inflammatory, non-contagious, chronic skin disorder that involves scaly and ...
Contact Dermatitis
Contact Dermatitis is a reaction of the skin in the form of skin rashes on coming into contact with ...
Dealing with Pollen Allergy
The plants around you that give you sniffles in your nose at specific time of the year are the sourc...
Dermatitis
Dermatitis is a group of skin conditions of varying causes marked by inflammation of the skin, chara...
Eczema: Miracles with Homeopathy
Eczema is a chronic inflammatory skin disease characterized by severe itching, redness, scaling and ...
Foods that are Bad for your Skin
Hydration, sebum formation and skin acidity determine the skin condition. Along with aging and envir...
Itchy Armpits
Itchy skin, also known as “pruritus”, is an irritating, discomforting condition. It affect men and w...
Scleroderma
Scleroderma or CREST syndrome is a chronic, auto immune disease which manifests as thick, dry, fibro...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use