The article entitled "Whole-Brain Connectivity in a Large Study of Huntington's Disease Gene Mutation Carriers and Healthy Controls" is coauthored by Jane Paulsen, University of Iowa, Iowa City, Flor Espinoza, The Mind Research Network and University, Albuquerque, NM, and colleagues. The scientists looked for correlations between the number of trinucleotide (CAG) repeats (the disease-causing gene mutation) and measures of whole-brain connectivity obtained on resting-state functional magnetic resonance imaging (fMRI). They compared the data acquired from individual carriers of the
gene with various CAG repeat lengths and healthy control subjects.
‘The findings of the study could pave the way for understanding connectivity alterations in Huntington disease gene carriers.’
"This analysis expands on previous Huntington disease studies by investigating associations between CAG repeat length and whole brain resting fMRI connectivity and also performs association tests between the identified CAG dependent connectivity and motor and cognitive performance," states Bharat Biswal, PhD, Co-Editor-in-Chief of Brain Connectivity and Chair of Biomedical Engineering, New Jersey Institute of Technology. "These results provide a step forward in understanding connectivity alterations in Huntington disease gene carriers."