Mothers With Polycystic Ovary Syndrome May Increase Risk of Autism in Newborns

by Iswarya on  August 2, 2018 at 6:14 PM Women Health News
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Maternal polycystic ovary syndrome (PCOS) may increase the risk of autism in children when compared to other women without PCOS, reports a new study. The findings of the study are published in the journal Translational Psychiatry.
Mothers With Polycystic Ovary Syndrome May Increase Risk of Autism in Newborns
Mothers With Polycystic Ovary Syndrome May Increase Risk of Autism in Newborns

PCOS affects about one in ten women and is caused by elevated levels of the hormone testosterone. It is associated with fluid-filled sacs (called follicles) in the ovaries and with symptoms such as delayed onset of puberty, irregular menstrual cycles, and excess bodily hair.

Autism is a condition characterized by difficulties in social interaction and communication alongside unusually narrow interests, a strong preference for predictability, and problems adjusting to unexpected change. Some autistic people also have learning difficulties and delayed language, and many have sensory hypersensitivity. The signs of autism are evident in childhood even if the diagnosis is not made until later, and occurs in about 1% of the population.

The research team previously published work in 2015 which showed that before they are born, autistic children have elevated levels of 'sex steroid' hormones (including testosterone) which ' masculinize' the baby's body and brain. The discovery that prenatal sex steroid hormones are involved in the development of autism is one possible explanation for why autism is diagnosed more often in boys.

The scientists wondered where these elevated sex steroid hormones were coming from; one possible source is the mother. If she had higher levels of testosterone than usual, as is the case in women with PCOS, then some of the hormones might cross the placenta during pregnancy, exposing her unborn baby to more of this hormone, and changing the baby's brain development.

Using anonymous data from a large database of GP health records, the study looked at 8,588 women with PCOS and their first-born children, compared to a group of 41,127 women without PCOS. The team found that, even after taking into account other factors (like maternal mental health problems or complications during pregnancy), women with PCOS had a 2.3% chance of having an autistic child, compared with the 1.7% chance for mothers without PCOS.

The team stressed that the likelihood of having an autistic child is still very low, even among women with PCOS but finding this link provides an important clue in understanding one of the multiple causal factors in autism.

The team presented their findings at the International Meeting for Autism Research in 2016, and their findings were replicated in a Swedish study in the same year, adding to the reliability of the result.

The team also conducted two other studies using the same data and found that autistic women were more likely to have PCOS, and women with PCOS were more likely to have autism themselves. This strongly suggests that these two conditions are linked, probably because they both share elevated sex steroid hormone levels.

Adriana Cherskov, the Master's student who analyzed the data, and who is now studying medicine in the US, said: "This is an important piece of new evidence for the theory that autism is not only caused by genes but also by prenatal sex steroid hormones such as testosterone."

Professor Simon Baron-Cohen, Director of the Autism Research Centre, who supervised the research, said: "This new research is helping us understand the effects of testosterone on the developing fetal brain and the child's later behavior and mind. These hormonal effects are not necessarily independent of genetic factors, as a mother or her baby may have higher levels of the hormone for genetic reasons, and testosterone can affect how genes function."

Dr. Carrie Allison who co-supervised the research, said: "We need to think about the practical steps we can put in place to support women with PCOS as they go through their pregnancies. The likelihood is statistically significant but still small, in that most women with PCOS won't have a child with autism, but we want to be transparent with this new information."

Dr Rupert Payne from the University of Bristol Centre for Academic Primary Care, a GP and the expert on the team in using GP health record data for this type of research, said: "Autism can have a significant impact on a person's wellbeing, and on their parents, and many autistic people have significant health, social care, and special educational needs. This is an important step in trying to understand what causes autism. It is also an excellent example of the value of using anonymous routine healthcare data to answer vital medical research questions."

Source: Eurekalert

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