About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Increased Atherosclerosis Risk in Lupus Patients

by Sheela Philomena on January 28, 2011 at 10:29 AM
Font : A-A+

 Increased Atherosclerosis Risk in Lupus Patients

Researchers have uncovered the link to increased risk of atherosclerosis in patients with systemic lupus erythematosus (SLE) condition. Interferon-alpha (IFN-a) is shown to be the cause of this increased risk. For the first time, IFN-a priming was shown to promote lipid uptake and foam cell formation - a crucial step in plaque build-up. This activation of the IFN signaling pathway may be linked to the premature atherosclerosis risk in SLE. Findings of this research is published in the February issue of Arthritis & Rheumatism.

SLE or lupus is a chronic, multisystem autoimmune disease that causes wide-spread inflammation in the body and can affect multiple organs. The Lupus Foundation of American estimates that up to 1.5 million Americans and more than 5 million people worldwide have some form of lupus (systemic, discoid, or drug-induced), which occurs more frequently in women. While prior studies have established that SLE patients demonstrated an increased incidence of premature atherosclerosis, they do not explain what may cause the greater cardiovascular risk.

Advertisement

"Although traditional risk factors such as hypertension, high cholesterol, and diabetes mellitus are thought to be important in mediating an increased risk for atherosclerosis in SLE, they fail to adequately explain the higher incidence of atherosclerotic diseases in SLE patients," said Nan Shen, M.D., Director of the Shanghai Institute of Rheumatology at Ren Ji Hospital and lead author of the study. To further investigate the cause of premature atherosclerosis in SLE, researchers recruited 42 patients with lupus and 42 healthy volunteers for their study. Blood samples were taken from all participants and peripheral blood monocytes were isolated and analyzed. Peripheral blood mononuclear cells (PBMCs) play an important role in the immune system's ability to fight infection.

Research data suggested that IFN-a priming promoted the formation of macrophage-derived foam cells in SLE patients. Specifically, researchers found macrophage scavenger receptor A (SR-A) expression by IFN-a was associated with enhanced lipid uptake and an increased number of foam cells. The initiating force for the occurrence of atherosclerosis is the accumulation of cholesterol-laden foam cells in the arterial wall. The team also established that expression of SR-A was significantly elevated in PBMCs of lupus patients and was positively correlated with IFN signaling activity.
Advertisement

Dr. Shen concluded, "Our findings further understanding of the mechanisms involved in the development of atherosclerosis in autoimmune disease and may provide potential therapeutic targets for the prevention and treatment of premature cardiovascular disease in lupus patients."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Ways to Manage Stress during COVID-19 Pandemic
Can Adjusting Fatty Acid Intake Improve Mood in Bipolar Disorder Patients?
Insulin Resistance Doubles the Risk of Major Depressive Disorder
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cholesterol Heart Attack Cholesterol - The Enigma Chemical Aplastic Anemia Atherosclerosis Aortic Dissection Renal Artery Stenosis Cholesteryl Ester Storage Disease Abdominal Aortic Aneurysm Atherectomy 

Recommended Reading
Quiz on Hypertension
It stealthily creeps in and catches people unawares. Find out more about this 'silent killer' by ......
Type 2 Diabetes
Learn more about Type 2 Diabetes, a disease that is taking the world by storm!...
Antioxidant Protein Promotes Atherosclerosis
Researchers of University of California have recently discovered that a protein Nrf2, plays a vital ...
Abdominal Aortic Aneurysm
The dilatation and localized bulging of a part of aorta in the abdominal part of patient’s body owin...
Aortic Dissection
Aortic dissection refers to a serious condition where there is a tear in the wall of a major artery ...
Aplastic Anemia
Aplastic anemia (AA) is a term that refers to a condition where the body fails to produce enough blo...
Atherosclerosis
Atherosclerosis is a condition in which the arteries become hard and narrow, leading to restricted b...
Cholesterol
Cholesterol is produced by the body (liver) and is essential for normal body functioning....
Cholesterol - The Enigma Chemical
The word 'Cholesterol' rings danger bells as soon as it is mentioned. This important chemical is im...
Cholesteryl Ester Storage Disease
Cholesteryl ester storage disease (CESD) is a rare inherited disease that results from the accumulat...
Heart Attack
Heart attack is the death of the heart muscle due to loss of blood supply. Heart disease is the lead...
Renal Artery Stenosis
Renal artery stenosis (RAS) is the narrowing of one or both arteries carrying blood to the kidneys....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use