The interim trial results show that hydroxychloroquine and lopinavir/ritonavir produce little or no reduction in the mortality of hospitalized COVID-19 patients.
Coronavirus
Coronaviruses infect animals, humans, and birds. Human coronaviruses, such as SARS, MERS, and 2019-nCoV cause respiratory distress and even death. The S protein is the infectious agent of the virus.
Coronaviruses infect animals, humans, and birds. Human coronaviruses, such as SARS, MERS, and 2019-nCoV cause respiratory distress and even death. The S protein is the infectious agent of the virus.
‘WHO has discontinued the use of hydroxychloroquine and lopinavir/ritonavir for COVID-19 treatment.’
"These interim trial results show that hydroxychloroquine and lopinavir/ritonavir produce little or no reduction in the mortality of hospitalized Covid-19 patients when compared to standard of care. Solidarity trial investigators will interrupt the trials with immediate effect," the WHO said in a press release, Xinhua reported. But the organization said this decision applies only to hospitalized patients and does not affect the possible evaluation in other studies of hydroxychloroquine or lopinavir/ritonavir in non-hospitalised patients or as pre- or post-exposure prophylaxis for Covid-19.
The Solidarity Trial was established by the WHO in March to find an effective Covid-19 treatment for hospitalised patients. It was originally designed to have five trial arms, including standard or usual care provided to Covid-19 patients, remdesivir, lopinavir/ritonavir combined, lopinavir/ritonavir combined with interferon beta, and hydroxychloroquine or chloroquine.
COVID-19 in Britain: Deaths Rise to 44,198
COVID-19 deaths in Britain have risen to 44,198, said the British Department of Health and Social Care.
COVID-19 deaths in Britain have risen to 44,198, said the British Department of Health and Social Care.
Source-IANS
Hydroxychloroquine
This medication is an antimalarial agent, prescribed for malaria, rheumatoid arthritis, and lupus erythematous.
This medication is an antimalarial agent, prescribed for malaria, rheumatoid arthritis, and lupus erythematous.
Lopinavir and Ritonavir
This combination medication contains antiretroviral agents, prescribed for HIV-1 infection for adults and children aged above 14 days.
It works by decreasing the amount of HIV in the blood by blocking a vital enzyme named protease required for viral multiplication.
Update:
• Ritonavir+ Lopinavir combination is claimed to treat patients with COVID-19.
• New clinical trial ‘’The Efficacy of Lopinavir Plus Ritonavir and Arbidol Against Novel Coronavirus Infection (ELACOI)’’ was started in February 2020 to know the effectiveness of the combination for treating COVID-19.
• Another trial sponsored by Asan Medical Center, launched in March 2020 is comparing Lopinavir/Ritonavir with Hydroxychloroquine for treating patients with mild coronavirus disease (COVID-19).
This combination medication contains antiretroviral agents, prescribed for HIV-1 infection for adults and children aged above 14 days.
It works by decreasing the amount of HIV in the blood by blocking a vital enzyme named protease required for viral multiplication.
Update:
• Ritonavir+ Lopinavir combination is claimed to treat patients with COVID-19.
• New clinical trial ‘’The Efficacy of Lopinavir Plus Ritonavir and Arbidol Against Novel Coronavirus Infection (ELACOI)’’ was started in February 2020 to know the effectiveness of the combination for treating COVID-19.
• Another trial sponsored by Asan Medical Center, launched in March 2020 is comparing Lopinavir/Ritonavir with Hydroxychloroquine for treating patients with mild coronavirus disease (COVID-19).
