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General Information on Lopinavir and Ritonavir

Generic Name : Lopinavir and Ritonavir

Pronunciation : loe pin' a veer- ri toe' na veer

Latest prescription information about Lopinavir and Ritonavir. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y41.5 | Therapeutic Classification : Antiretroviral Agents

Trade Names/Brand Names of Lopinavir and Ritonavir

International- Kaletra and Aluvia.

Why is Lopinavir and Ritonavir Prescribed? (Indications)

This combination medication contains antiretroviral agents, prescribed for HIV-1 infection. It works by decreasing the amount of HIV in the blood.

When should Lopinavir and Ritonavir not to be taken? (Contraindications)

It should not be co-administered with highly dependent on CYP3A(a gene) for clearance and HMG-CoA Reductase inhibitors. Contraindicated in patients with known hypersensitivity.

What is the dosage of Lopinavir and Ritonavir?

PO- The recommended dose is 200/50 tablets, two twice daily or four, once daily; Oral solution, 5 mL twice daily or 10 mL once daily with food.

How should Lopinavir and Ritonavir be taken?

It comes as a tablet to take by mouth, with or without food.

What are the warnings and precautions for Lopinavir and Ritonavir?

Caution should be exercised in patients with history of QT prolongation, irregular heartbeat, decrease in blood minerals, hemophilia, high cholesterol, swelling of the pancreas, heart or liver disease, any allergy, who are taking other medications, during pregnancy and breastfeeding.

Monitor cholesterol and triglyceride levels, viral load, and liver function regularly while taking this medication.

It does not stop the spread of infection to others; avoid sexual contact, sharing of needles, injection supplies.

What are the side effects of Lopinavir and Ritonavir?

   Most Common : Diarrhea.
   Gastrointestinal : Nausea, vomiting, abdominal pain, indigestion, flatulence.
   General : Weakness.
   Metabolic: Decreased weight and appetite.
   Musculoskeletal : Muscle pain.
   Central Nervous System : Headache, tingling, sleeplessness, depression, libido decreased.
   Skin : Rash.
   Heart : Dilatation of blood vessels.

What are the other precautions for Lopinavir and Ritonavir?

Avoid excess dosage.

What are the storage conditions for Lopinavir and Ritonavir?

Capsules and solution should be refrigerated at 2-8C (36-46F). If stored at room temperature, the capsules and solution should be used within 2 months.

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