About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
New Treatment for Chronic Migraine Sufferers
Advertisement

New Treatment for Chronic Migraine Sufferers

Font : A-A+

Highlights:
  • People suffering from migraine have disruptions in their neuronal flexibility
  • About 14% of the world population is suffering from migraine
  • The new migraine therapy helps restore microtubule or the neuronal plasticity

New way to treat chronic migraine has been discovered by researchers, where a new cellular mechanism helps prevent migraines by restoring neuronal plasticity.

Amynah Pradhan, associate professor of psychiatry at the University of Illinois Chicago, is the senior author of the study, whose goal was to identify a new mechanism of chronic migraine, and propose a cellular pathway for migraine therapies.

Advertisement


The study, "Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition, is published in eLife.

Pradhan, whose research focus is on the neurobiology of pain and headache, explained that the dynamic process of routing and rerouting connections among nerve cells, called neural plasticity, is critical to both the causes and cures for disorders of the central nervous system such as depression, chronic pain, and addiction.
Advertisement

The structure of the cell is maintained by its cytoskeleton which is made up of the protein, tubulin. Tubulin is in a constant state of flux, waxing and waning to change the size and shape of the cell. This dynamic property of the cell allows the nervous system to change in response to its environment.

Tubulin is modified in the body through a chemical process called acetylation. When tubulin is acetylated it encourages flexible, stable cytoskeleton; while tubulin deacetylation - induced by histone deacetylase 6, or HDAC6, promotes cytoskeletal instability.

Studies in mice models show that decreased neuronal complexity may be a feature, or mechanism, of chronic migraine, Pradhan said. When HDAC6 is inhibited, tubulin acetylation and cytoskeletal flexibility is restored. Additionally, HDAC6 reversed the cellular correlates of migraine and relieved migraine-associated pain, according to the study.

"This work suggests that the chronic migraine state may be characterized by decreased neuronal complexity, and that restoration of this complexity could be a hallmark of anti-migraine treatments. This work also forms the basis for development of HDAC6 inhibitors as a novel therapeutic strategy for migraine," the researchers report.

Pradhan said this research reveals a way to possibly reset the brain toward its pre-chronic migraine state.

"Blocking HDAC6 would allow neurons to restore its flexibility so the brain would be more receptive to other types of treatment. In this model we are saying, maybe chronic migraine sufferers have decreased neuronal flexibility. If we can restore that complexity maybe we could get them out of that cycle," she said.

Once out of the cycle of decreased neuronal complexity, the brain may become more responsive to pain management therapies, Pradhan said. HDAC6 inhibitors are currently in development for cancer, and HDCA6 as a target has been identified for other types of pain.

"It opens up the possibility of something we should be looking at on a broader scale," she said. "Are these changes maybe a hallmark of all sorts of chronic pain states?"

Migraine is a common brain disorder that is estimated to affect 14% of the world population. Current U.S. cost estimates for migraine are as high as $40 billion annually. One particularly debilitating subset of migraine patients are those with chronic migraine, defined as having more than 15 headache days a month.

Migraine therapies are often only partially effective or poorly tolerated, creating a need for more diverse drug therapies.



Source: Eurekalert

Citations   close

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Hannah Joy. (2021, May 06). New Treatment for Chronic Migraine Sufferers. Medindia. Retrieved on Jun 25, 2022 from https://www.medindia.net/news/healthwatch/new-treatment-for-chronic-migraine-sufferers-201083-1.htm.

  • MLA

    Hannah Joy. "New Treatment for Chronic Migraine Sufferers". Medindia. Jun 25, 2022. <https://www.medindia.net/news/healthwatch/new-treatment-for-chronic-migraine-sufferers-201083-1.htm>.

  • Chicago

    Hannah Joy. "New Treatment for Chronic Migraine Sufferers". Medindia. https://www.medindia.net/news/healthwatch/new-treatment-for-chronic-migraine-sufferers-201083-1.htm. (accessed Jun 25, 2022).

  • Harvard

    Hannah Joy. 2021. New Treatment for Chronic Migraine Sufferers. Medindia, viewed Jun 25, 2022, https://www.medindia.net/news/healthwatch/new-treatment-for-chronic-migraine-sufferers-201083-1.htm.

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
COVID Toes
International Yoga Day 2022 - 'Yoga for Humanity'
Wearable Devices Are Now Transforming Depression, Multiple Sclerosis, and Epilepsy Management.
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Migraine Headache / Cephalgia Headache Symptom Evaluation Retinal Migraine / Ocular Migraine Menstrual Migraine Drug Induced Headache 

Most Popular on Medindia

A-Z Drug Brands in India Blood Pressure Calculator Daily Calorie Requirements Iron Intake Calculator Sanatogen Blood Donation - Recipients Sinopril (2mg) (Lacidipine) Drug Side Effects Calculator Accident and Trauma Care Hearing Loss Calculator

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use