Ferrer-Montiel and his team reviewed decades of literature on sex hormones, migraine sensitivity and the responses of the cells to migraine triggers to identify the role of specific hormones.
However, Ferrer-Montiel says that since the role of estrogen and other hormones in a migraine is complex, the current work is preliminary and a lot more research is needed to understand it. He stresses on the need for longitudinal studies that focus on the
. Besides, the current work relies on in vitro and animal models that are tough to translate into human migraine sufferers.
‘Latest research has revealed a potential mechanism by which migraines are caused which could explain why women suffer more from them compared to men.’
Nonetheless, the authors see a promising future for migraine medication in their current findings. They plan to continue their research using pre-clinical, human-based models that better represent real patients.
"If successful, we will contribute to better personalized medicine for migraine therapy," he says.
Migraines
Migraines typically cause a throbbing or a pulsing kind of pain that could be moderate to severe in degree. The pain is usually felt on one side of the head. The associated symptoms could be nausea, vomiting, and sensitivity to light and sound.
Migraines are more likely to occur in women, in people who have a family history of migraines, and those having medical conditions like
depression, anxiety, bipolar disorder, sleep disorders and epilepsy.
Migraines have a lot of triggers including stress, anxiety, fatigue,
hormonal changes in women, certain foods and medications, and weather fluctuations.
Estrogen levels have been linked before with women who have a migraine history - these women were shown to have a faster decline rate of estrogen levels regardless of whether they had a migraine during that period cycle or not.
References :
- Maite Artero-Morales, Sara González-Rodríguez and Antonio Ferrer-Montiel., TRP Channels as Potential Targets for Sex-Related Differences in Migraine Pain" Cellular Biochemistry 14 August (2018) https://doi.org/10.3389/fmolb.2018.00073
- Migraine
(https://medlineplus.gov/migraine.html)
Source: Medindia
