About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Method to Block Chemotherapy-induced Neuropathic Pain Identified

Font : A-A+

Highlights:
  • A way to block neuropathic pain caused by chemotherapy has been identified.
  • This can be done by blocking the interactions between molecular-level components that lead to the pain.
  • Blocking of these pain-causing interactions does not interfere with the properties of the anti-cancer drugs.

Method to Block Chemotherapy-induced Neuropathic Pain Identified

Knowing the pathway of the pain may help prevent the pain
The excruciating pain that often accompanies a colorectal cancer drug has been turned off successfully in animal models, research at the Saint Louis University (SLU) claims.

Pathways of the pain, the series of interactions between molecular-level components that lead to pain in the body has been studied by Daniela Salvemini, Ph.D., professor of pharmacology and physiology at SLU.

Advertisement


The pain that was studied in the research is chemotherapy induced neuropathic pain (CINP) which is a debilitating side effect of chemotherapy that can appear as tingling or numbness in the hands and feet, shooting or burning pain in the limbs, or can feel like hot or cold temperature extremes. Besides causing pain, it is also a limiting factor to treatments.

"Thanks to the increased efficacy of cancer treatment, there are nearly 14 million cancer survivors in the United States," Salvemini said. "Many of these survivors suffer from long-term side effects of CINP, for which there are no proven strategies for prevention or treatment.
Advertisement

"This is a huge unmet medical need."

Salvemini has studied the platinum-based chemotherapy drug oxaliplatin which is widely used to treat colorectal cancer where she observed that more than 60 percent of patients who received oxaliplatin develop CINP, and it can last for years after treatment.

The role of adenosine kinase in chemotherapy-induced pain
The pathway of the pain caused by the drug was driven by increased expression of an enzyme, adenosine kinase, in astrocytes (a type of central nervous system cell) and decreased adenosine signaling at a key receptor, A3AR.

The researchers were able to block the development of CINP without interfering with the anticancer properties of platinum-based drugs by supplementing this signaling with A3AR agonists.

The findings of this research provide new insight into the pathway of pain induced by chemotherapy drugs and provide new information about how drugs may be able to treat chemotherapy pain.

References :
  1. Carrie Wahlman, Timothy M. Doyle et al. Chemotherapy-induced Pain is Promoted by Enhanced Spinal Adenosine Kinase Levels through Astrocyte-dependent Mechanisms, Ovid DOI: 10.1097/j.pain.0000000000001177


Source: Medindia

Citations   close

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World Disability Day 2022 - The Role of Innovative Transformation
Diet and Oral Health: The Sugary Connection May Become Sour
World AIDS Day 2022 - Equalize!
View all
Recommended Reading
News Archive
Date
Category
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Thoracic Outlet Syndrome Exercising Tips For Nerve Pain Relief Allodynia 

Most Popular on Medindia

Hearing Loss Calculator Blood Pressure Calculator Blood - Sugar Chart The Essence of Yoga Diaphragmatic Hernia How to Reduce School Bag Weight - Simple Tips Loram (2 mg) (Lorazepam) Accident and Trauma Care A-Z Drug Brands in India Sanatogen
open close
ASK A DOCTOR ONLINE

×

Method to Block Chemotherapy-induced Neuropathic Pain Identified Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests