Metabolic Syndrome Increases Risk of Colorectal Cancer In Normal Weight Women

Elevated waist circumference, hypertension, elevated levels of triglycerides, blood glucose, and low levels of HDL-C indicates metabolic syndrome.

Highlights

Colorectal cancer is the third most commonly diagnosed cancer for women in the United States.
Women with normal body weight but at risk of metabolic syndrome may develop colorectal cancer.
Hypertension, elevated levels of triglycerides, blood glucose, and low levels of HDL-C indicate poor metabolic health.

Poor metabolic health is usually associated with obesity but 30% of normal-weight adults are believed to be metabolically unhealthy worldwide.

Metabolic health is often assessed by measuring waist circumference, blood pressure, and levels of triglycerides, glucose, and high-density lipoprotein cholesterol (HDL-C, so-called "good" cholesterol) in the blood.

Colorectal Cancer - Types, Causes, Risk Factors, Symptoms, Diagnosis, Treatment, Prognosis & Prevention
Colorectal cancer is a cancer that starts in the colon or the rectum. Colorectal cancer is the third most common cancer in men.

‘Women with metabolic syndrome had more than two-fold higher risk for colorectal cancer relative to those who were metabolically healthy.’

People have metabolic syndrome if they have three or more of the following: elevated waist circumference, elevated blood pressure, elevated levels of triglycerides, elevated levels of glucose, and low levels of HDL-C.

In this study, people were considered metabolically unhealthy if they had two or more of those factors excluding elevated waist circumference.

Liang and colleagues used data from 5,068 postmenopausal women enrolled in the Women's Health Initiative. All the women were classed as normal weight based on having a body mass index (BMI) from 18.5 kg/m2 to <25 kg/m2; 33.7 percent of them were metabolically unhealthy.

Colorectal Cancer Screening
Colorectal screening is done using tests to detect blood in stool, colonoscopy or sigmoidoscopy ordouble contrast barium enema or CT colonography.

During a mean follow-up time of 14.3 years, 64 of the 3,358 women who were classed as metabolically healthy were diagnosed with colorectal cancer and 50 of the 1,710 metabolically unhealthy women.

After adjusting for numerous factors that affect colorectal cancer risk, the researchers calculated that women who were metabolically unhealthy had a 49 percent increased risk for colorectal cancer relative to those who were metabolically healthy.

Colo-rectal Cancer - Management
Treatment for Colorectal Cancers may involve surgery,chemotherapy, radiation therapy or biological therapy. Some people require a combination of treatments.

The researchers also found that women with metabolic syndrome had a more than two-fold higher risk for colorectal cancer relative to those who were metabolically healthy.

"Our finding that normal-weight U.S. women who are metabolically unhealthy have an increased risk of colorectal cancer compared with those who are metabolically healthy,” said Liang.

Metabolic Syndrome - About
Metabolic Syndrome is associated with sedentary lifestyle .It makes a person more prone to develop type 2 diabetes and coronary artery disease.

The study highlights how important it is for women to be aware of their metabolic health status, which can be assessed using standard clinical tests.

"Colorectal cancer is the third most commonly diagnosed cancer for women in the United States," she continued. "Recognition that normal-weight women who are metabolically unhealthy may have an increased risk for colorectal cancer could result in more timely use of preventive interventions and reduce the burden of this deadly disease."

According to Liang, the study had two main limitations. First, BMI and components of metabolic health were measured only at the time of enrollment in the Women's Health Initiative and possible changes over time could not be considered in the analysis. Second, the study population can be generalized only to postmenopausal women and not men or younger women.

Reference

Xiaoyun Liang, Poor metabolic health in some normal-weight women may increase risk for colorectal cancer, Cancer Epidemiology, Biomarkers & Prevention (2017).

Source-Medindia