Genes Make Fat Easy to Gain and Hard to Lose!

Trying to lose weight but still find no improvement? It’s not your diet but your genes. The more fatter you are, the more it is difficult for you to lose weight due to a gene that triggers fat storage, revealed a new study.In a new study published in the Journal Nature Communications, a team of researchers from the University of Cambridge have discovered a gene that triggers cells to store fat which in turn makes it harder for people to lose weight.

"Our discovery may help explain why overweight individuals find it incredibly hard to lose weight. Their stored fat is actively fighting against their efforts to burn it off at the molecular level." said the study's co-author Dr. Andrew Whittle, a metabolic researcher at the University of Cambridge.

The gene produces a protein sLR11 fats. Researchers examined this gene, which produces a protein sLR11. The protein inhibits thermogenesis, a process of burning fats with heat. They found that people who are overweight have higher number of this suppressor proteins that makes it difficult for them to lose weight.

Researchers suspect that protein sLR11's role may be to make a more effective storing system in the body to maintain energy and body temperature over long periods of time. This research could also pave for developing drugs that blocks the action of this protein or control weight loss by mimicking its action.

Reference: Whittle JA, Jiang M, and Peirce V, et al. “Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans,” Nature Communications. 2015, doi:10.1038/ncomms9951

Source-Medindia