Low doses of Bisphenol A (BPA) contribute to a large range of health problems such as polycystic ovarian syndrome, immune response to allergens, behavioural problems and decreased fertility in humans, say researchers.
For the past decade, scientists have used modern scientific techniques to probe the effects of BPA on numerous endpoints that are not examined in those traditional toxicology studies.
Examining these non-traditional endpoints reveal a very different story. Because of increased understanding of the mechanisms by which hormones and chemicals that mimic hormones work, it has recently become clear that endocrine disruptors need to be studied at much lower doses.
When looking at the "low dose" literature as a whole, reproducible effects were seen in animals after exposure to incredibly low doses of BPA. In fact, effective doses were ten to forty times lower than the doses identified in traditional toxicology studies. Several dozen "low dose" studies show effects of BPA at doses that humans are thought to encounter in their everyday lives.
With the knowledge that such tiny amounts of BPA can have such far-reaching implications for humans and wildlife, stricter regulations of this chemical and other endocrine disruptors should be fast on its heels.
The study is published in journal Landes Bioscience.