About Careers Internship MedBlog Contact us

Cancer Pain Inducing Gene Identified, Paves Way for Targeted Pain Therapies

by Julia Samuel on April 28, 2015 at 5:49 PM
Font : A-A+

Cancer Pain Inducing Gene Identified, Paves Way for Targeted Pain Therapies

Pain management in cancer patients is crucial and scientists have discovered the trigger behind the most severe forms of cancer pain that can potentially lead to better pain management.

The study identified a gene that is also responsible for some of the most aggressive forms of androgen-fuelled cancers. Visible on the surface of the cancer cells, the gene TMPRSS2 comes in contact with the body's nerve pain receptors, which then trigger the pain.


"Prostate cancer research already knows that if you have the TMPRSS2 gene marker, the prostate cancer is much more aggressive. They've also shown that this is androgen (male hormone) sensitive," said lead researcher David Lam, University of Toronto.

In this study, Lam found that this gene was not only present in patients suffering from head and neck cancers, it was also prevalent in much greater quantities in prostate cancer. The more TMPRSS2 that comes into contact with nerve pain receptors, the greater the pain, found the researchers.

Lam and colleagues followed up this observation by looking at different types of cancers with known pain associations. According to clinical data, head and neck cancer are the most painful form of cancers, followed by prostate cancer, while melanoma, or skin cancer, is at the bottom of the pain scale.

But what surprised the researchers was that the presence and numbers of TMPRSS2 in these cancer cell cultures stood in exact correlation with the known level of pain each cancer causes.

The discovery of TMPRSS2's role in triggering cancer pain may lead to the creation of targeted cancer pain therapies that effectively shut down the expression of this gene or its ability to infiltrate pain receptors in the body.

Source: Medindia


Recommended Readings

Latest Cancer News

Combination Therapy may Benefit Leukemia Patients
The new study uncovers the efficacy of fixed-duration combination treatment in patients with high-risk leukemia.
 Myelofibrosis: New Drugs to Revolutionize Treatment
The approvals of pipeline drugs such as momelotinib and Vonjo for myelofibrosis (a rare type of blood cancer) over some time will handle the critical unmet needs.
 Blood Vessels Can Kill Cancer Cells and Stop Breast Cancer Spread
New study highlights the dual role that blood vessels can play in cancer immunotherapy and eliciting anti-tumor immune responses or even preventing breast cancer spread.
 Weed Killer Agent Orange May Increase the Risk of Blood Cancer Among Veterans
New study evaluated the association between exposure to the chemical agent orange and the development of blood cancer with increased bleeding and blood clot formation.
Two Years: Optimal Duration of Immunotherapy in Advanced Lung Cancer
Study suggests two-year immunotherapy treatment for advanced lung cancer may be reasonable
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Cancer Pain Inducing Gene Identified, Paves Way for Targeted Pain Therapies Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests