Brown fat is a heat organ that uses sugar, fat, and branched-chain amino acids from the blood to generate heat in the body. Hence, BCAA is beneficial for healthy people with active brown fat but can be dangerous for the elderly, obese, and diabetics.
Rutgers and other scientists have discovered how brown fat, also known as brown adipose tissue, may help protect against obesity and diabetes. Their study in the journal Natureadds to our knowledge about the role of brown fat in human health and could lead to new medications for treating obesity and type 2 diabetes.
Brown Fat to Fight Flab
Around 50 grams of white fat stores 300 kilocalories. In contrast the same amount of brown fat burns 300 kilocalories a day. Such is the magic of this good fat.
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‘Brown fat or brown adipose tissue helps protect against diabetes and obesity. This could lead to the discovery of new drugs for treating obesity and diabetes’
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Brown fat is considered a heat organ. People have a few grams of it in areas including the neck, collarbone, kidneys and spinal cord. When activated by cool temperatures, brown fat uses sugar and fat from the blood to generate heat in the body.
The study found that brown fat could also help the body filter and remove branched-chain amino acids (BCAAs) from the blood. BCAAs (leucine, isoleucine and valine) are found in foods like eggs, meat, fish, chicken and milk, but also in supplements used by some athletes and people who want to build muscle mass.
![FDA Approved Drug Found To Increase Brown Fat and Lower Weight Gain]( "FDA Approved Drug Found To Increase Brown Fat and Lower Weight Gain")
An FDA approved drug has been found to increase brown fat, boosting metabolism and lowering weight gain, providing a potential treatment for obesity.
In normal concentrations in the blood, these amino acids are essential for good health. In excessive amounts, they're linked to diabetes and obesity. The researchers found that people with little or no brown fat have reduced ability to clear BCAAs from their blood, and that may lead to the development of obesity and diabetes.
The study also solved a 20-plus year mystery about brown fat: how BCAAs enter the mitochondria that generate energy and heat in cells. The scientists discovered that a novel protein (called SLC25A44) controls the rate at which brown fat clears the amino acids from the blood and uses them to produce energy and heat.
"Our study explains the paradox that BCAA supplements can potentially benefit those with active brown fat, such as healthy people, but can be detrimental to others, including the elderly, obese and people with diabetes," said co-author Labros S. Sidossis, a Distinguished Professor who chairs the Department of Kinesiology and Health in the School of Arts and Sciences at Rutgers University-New Brunswick. He is also a professor in the Department of Medicine at Rutgers Robert Wood Johnson Medical School in Rutgers Biomedical and Health Sciences.
Researchers next need to determine whether uptake of BCAAs by brown fat can be controlled by environmental factors - such as exposure to mildly cold temperatures (65 degrees Fahrenheit) or consumption of spicy foods - or by drugs. This could improve blood sugar levels that are linked to diabetes and obesity, Sidossis said.
Source: Eurekalert
FDA Approved Drug Found To Increase Brown Fat and Lower Weight Gain
An FDA approved drug has been found to increase brown fat, boosting metabolism and lowering weight gain, providing a potential treatment for obesity.
Advertisement
In normal concentrations in the blood, these amino acids are essential for good health. In excessive amounts, they're linked to diabetes and obesity. The researchers found that people with little or no brown fat have reduced ability to clear BCAAs from their blood, and that may lead to the development of obesity and diabetes.
The study also solved a 20-plus year mystery about brown fat: how BCAAs enter the mitochondria that generate energy and heat in cells. The scientists discovered that a novel protein (called SLC25A44) controls the rate at which brown fat clears the amino acids from the blood and uses them to produce energy and heat.
"Our study explains the paradox that BCAA supplements can potentially benefit those with active brown fat, such as healthy people, but can be detrimental to others, including the elderly, obese and people with diabetes," said co-author Labros S. Sidossis, a Distinguished Professor who chairs the Department of Kinesiology and Health in the School of Arts and Sciences at Rutgers University-New Brunswick. He is also a professor in the Department of Medicine at Rutgers Robert Wood Johnson Medical School in Rutgers Biomedical and Health Sciences.
Researchers next need to determine whether uptake of BCAAs by brown fat can be controlled by environmental factors - such as exposure to mildly cold temperatures (65 degrees Fahrenheit) or consumption of spicy foods - or by drugs. This could improve blood sugar levels that are linked to diabetes and obesity, Sidossis said.
Source: Eurekalert
Inflammation Halts Brown Fat Cells to Burn Fat
he inflammation factor TNFalpha suppresses the cGMP signal path and thus prevents white fat cells from being turned into brown fat cells.
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 Impaired Brain Switch May Cause Obesity: Study RevealsThe imbalance in the balance between energy intake and energy expenditure due to feeding that controls browning of fat, may lead to obesity. | Advertisement
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