AIDS-related deaths are falling as ramped-up treatment begins to have an impact, says agency.
After years of dragging its heels on the HIV/AIDS crisis, since 2004 South Africa has developed the world's largest HIV treatment programme.
New data indicate that drive is working. The disease will be responsible for 32 percent of all deaths this year.
"Medicine has advanced and people are living with HIV and AIDS," statistician-general Pali Lehohla told AFP, unveiling data that point to a dramatic drop in AIDS-related deaths.
Average life expectancy has also increased to 59.6 years, from just 51.6 in 2005.
But the scale of the problem is huge, with 5.3 million people living with HIV out of a population of nearly 53 million.
The state had 1.9 million people on treatment in April this year.
Statistics South Africa released its last mid-year estimates, which uses modelled figures, in 2011.
The country's population growth rate is just over one percent.