93 Genes Triggering Breast Cancer Identified

Identification of genetic events that lead to breast cancer can pave the way for developing personalized treatments to overcome the disease.

Unpicking the genetic errors that cause breast cancer can help unlock new ways of treating the disease, said researchers.

Researchers from the Wellcome Trust Sanger Institute conducted a massive project comprising of DNA taken from 560 breast cancer patients. They analyzed the mutations that trigger the conversion of a breast cell into cancer cells.

Breast Cancer Gene May Play Other Roles Than DNA Repair
BRCA1 is known to suppress cancer by repairing breaks in DNA, the molecule that contains the genetic blueprint of each cell.

TOP INSIGHT

British Researchers identify 93 genes that are associated with breast cancer and targeting these genetic mutations can help in developing personalized breast cancer treatments.

Human genome is made up of 20,000 genes, out of which they found 93 genetic mutations also called as mutational signatures are associated with breast cancer.

Examining more into this 93 faulty genes and targeting them for drug development could help in developing personalized breast cancer treatments.

These 93 genes are said to be crucial as they put a person at an higher risk of developing breast cancer. The team hope that they will be able to tailor treatment to the genetic make-up of the individual. The findings were published in the Journal Nature Communications.

Increased Risk With New Breast Cancer Gene Mutation
A new gene mutation has been discovered which raises a woman's risk of breast cancer and may be considered the third such inherited gene flaw known to science, researchers said Wednesday.

Professor Sir Mike Stratton, director of the Wellcome Trust Sanger Institute, said, "This huge study, examining in great detail the many thousands of mutations present in each of the genomes of 560 cases brings us much closer to a complete description of the changes in DNA in breast cancer and thus to a comprehensive understanding of the causes of the disease and the opportunities for new treatments."

Source-Medindia

Increased Chances of Survival After Double Mastectomy for Women With Breast Cancer Gene Mutation
Increased chances of survival found in women who carry a mutation on the BRCA breast cancer gene, diagnosed with early stage breast cancer and also undergo a double mastectomy.

Scientists Discover New Drug Targets for Aggressive Breast Cancer
Genes that are potential targets for therapeutic drugs against aggressive breast cancer have been discovered by Genome Institute of Singapore scientists.