Are you taking ketoconazole? Are you aware of the dangers of combining ketoconazole with certain foods, herbs, or alcohol? Drug-food-interactions are seldom discussed but can lead to undesirable side effects and potentially diminish the efficacy of the medication.
St.John's wort: Ketoconazole interacts with St. John's wort resulting in decreased Ketoconazole exposure(1✔ ✔Trusted Source
Avoid Food-Drug Interactions: A Guide from the National Consumers League and U.S. Food and Drug Administration.
Go to source).
Effect of the CYP3A inhibitor ketoconazole on the PXR-mediated induction of CYP3A activity
Go to source).
References
1. Avoid Food-Drug Interactions: A Guide from the National Consumers League and U.S. Food and Drug Administration.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/018533s041lbl.pdf
2. Effect of the CYP3A inhibitor ketoconazole on the PXR-mediated induction of CYP3A activity
https://pubmed.ncbi.nlm.nih.gov/22968811/#:~:text=Conclusions%3A%20Ketoconazole%20is%20a%20strong,induction%20of%20CYP3A%20in%20vivo.
3. National Library of Medicine: Ketoconazole MedlinePlus Drug Information
https://medlineplus.gov/druginfo/meds/a682816.html
ketoconazole Interactions with Food and Herbs
Grapefruit juice: Avoid grapefruit juice while taking Ketoconazole, as it may result in increased Ketoconazole exposure.St.John's wort: Ketoconazole interacts with St. John's wort resulting in decreased Ketoconazole exposure(1✔ ✔Trusted Source
Avoid Food-Drug Interactions: A Guide from the National Consumers League and U.S. Food and Drug Administration.
Go to source).
ketoconazole Interactions with Alcohol
Do not drink alcohol while taking Ketoconazole as it may result in disulfiram-like reaction such as tachycardia, flushing, vomiting, and increased respiratory rate(2✔ ✔Trusted SourceEffect of the CYP3A inhibitor ketoconazole on the PXR-mediated induction of CYP3A activity
Go to source).
When and How to Take ketoconazole
- Ketoconazole is available in the form of a tablet to be taken orally. It is usually taken once a day at around the same time everyday. It also comes as a cream and a shampoo to apply to the skin.
- Follow the instructions as directed by the physician.
- Do not exceed or miss the dose.
- Do not discontinue the medication even if you feel better without consulting the physician(3✔ ✔Trusted Source
National Library of Medicine: Ketoconazole MedlinePlus Drug Information
Go to source).
References
1. Avoid Food-Drug Interactions: A Guide from the National Consumers League and U.S. Food and Drug Administration.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/018533s041lbl.pdf
2. Effect of the CYP3A inhibitor ketoconazole on the PXR-mediated induction of CYP3A activity
https://pubmed.ncbi.nlm.nih.gov/22968811/#:~:text=Conclusions%3A%20Ketoconazole%20is%20a%20strong,induction%20of%20CYP3A%20in%20vivo.
3. National Library of Medicine: Ketoconazole MedlinePlus Drug Information
https://medlineplus.gov/druginfo/meds/a682816.html
