Acalabrutinib : Interaction with Foods, Herbs & Alcohol

Last Updated on Jul 26, 2023

Are you taking Acalabrutinib? Are you aware of the dangers of combining Acalabrutinib with certain foods, herbs, or alcohol? Drug-food-interactions are seldom discussed but can lead to undesirable side effects and potentially diminish the efficacy of the medication.

Acalabrutinib Interactions with Food and Herbs

Grapefruit: Interaction of grapefruit juice with Acalabrutinab inhibits CYP3A metabolism and increases the serum concentration of this drug ().

St.John's Wort: This herb stimulates CYP3A metabolism and reduces serum level of Acalabrutinib ().

Curcumin: Acalabrutinib, when taken with curcumin, may decrease its metabolism ().

Acalabrutinib Interactions with Alcohol

Drinking a small amount of alcohol does not affect the efficacy of Acalabrutinib. If this drug is used during pregnancy it may harm the baby ().

When and How to Take Acalabrutinib

Acalabrutinib is available only on prescription. It comes in the form of a capsule to be taken orally.
You may take it twice a day preferably with or without food. Take this drug at least 2 hours before or after taking antacids.
Follow the directions exactly as given on the prescription label. Take the capsules with a full glass of water.
Stick to the recommended dose and do not skip the prescribed dose of medicine without consulting your doctor (2^✔ ✔Trusted Source
National Library of Medicine; Acalabrutinib: MedlinePlus Drug Information

Go to source).

References

1. Pilla Reddy V, Jo H, Neuhoff S. Food constituent- and herb-drug interactions in oncology: Influence of quantitative modelling on Drug labelling.Br J Clin Pharmacol. 2021 Oct;87,(10):3988-4000. doi: 10.1111/bcp.14822. Epub 2021 Apr 14. PMID: 33733472.
2. National Library of Medicine. Acalabrutinib: MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a604025.html

Drug Name : Acalabrutinib

Acalabrutinib is prescribed to treat a type of blood cancer called mantle cell lymphoma (MCL) in adult patients who are already treated with one chemotherapy medication. Acalabrutinib works by arresting the growth of cancer cells.

We recommend consulting your doctor to verify the information presented on this page or if you need any further clarifications.

Learn More about Drug-Food Interactions to Safeguard Your Health

1	Be Aware of Common Drug-Food Interactions

2	Grapefruit Can Work Against Your Drug

3	Interaction of Antibiotics with Dairy Products

4	Drug Interaction with Alcohol

5	Test Your Knowledge on Drug Interaction

6	Ten Common Drug-Drug interactions