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Last Updated : Jul 2018

General Information on Acalabrutinib

Generic Name : Acalabrutinib

Pronunciation : a-KAL-a-BROO-ti-nib

Latest prescription information about Acalabrutinib. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Chemotherapy

Trade Names/Brand Names of Acalabrutinib

Calquence

Overview of Acalabrutinib

Acalabrutinib is an anti-cancer agent which was approved by the US FDA in October 2017 for treating mantle cell lymphoma (MCL).

Why is Acalabrutinib Prescribed? (Indications)

Acalabrutinib is prescribed to treat a type of blood cancer called mantle cell lymphoma (MCL) in adult patients who are already treated with one chemotherapy medication.

Acalabrutinib works by arresting the growth of cancer cells. 

When should Acalabrutinib not to be taken? (Contraindications)

Acalabrutinib should not be used in in the following conditions-

Allergy to acalabrutinib
Pregnancy and breastfeeding
infection
Children below 18 years of age

What is the dosage of Acalabrutinib?

The recommended dose of acalabrutinib is 100mg which should be taken twice daily.
Dose modifications are recommended if adverse reactions of grade 3 or more occur.
The treatment with acalabrutinib can either be stopped until side effects resolve or it can be permanently discontinued depending on the seriousness of the reaction.

How should Acalabrutinib be taken?

Acalabrutinib comes as a capsule which should be taken by mouth either with or without food.
Acalabrutinib capsules should be swallowed with sufficient quantity of water.
Do not open or split or crush the contents of the capsule.
Take acalabrutinib capsules around the same time every day and take the dose exactly as advised.

What are the warnings and precautions for Acalabrutinib?

Patients taking acalabrutinib must be monitored for the signs of bleeding as acalabrutinb increases the risk of bleeding particularly in patients on anticoagulant or antiplatelet treatment.
Acalabrutinib treatment can be stopped temporarily for three to seven days before and after surgery to avoid the risk of bleeding.

Monitor patients for the signs of bacterial, viral or fungal infections which should be treated appropriately with adequate medical care. Patients at risk of opportunistic infections may require preventive treatment before starting acalabrutinib therapy.

Complete blood counts should be assessed every month during acalabrutinib therapy to detect low blood counts and to treat at the earliest.
Patients are advised to protect from sun exposure by using sunscreen and protective clothing as acalabrutinib can cause sunburn and result in other cancers such as skin cancer.

Atrial flutter and atrial fibrillation can occur in patients on acalabrutinib therapy. These should be treated with appropriate medical care and related supportive therapy.

What are the side effects of Acalabrutinib?

  Common: Diarrhea, headache, muscle ache, tiredness, bruising, bleeding
  Gastrointestinal: Nausea, pain in the stomach, vomiting, constipation
  Cardiovascular: Bleeding events, irregular heartbeat, atrial flutter or fibrillation
  Blood: Reduced number of red blood cells, white blood cells or platelets
  Skin: Rashes, bruises, skin cancer
  Others: Nasal bleeding, increased level of creatinine in blood, serious infections including pneumonia and reactivation of hepatitis B infection, other cancers

What are the other precautions for Acalabrutinib?

If a dose is missed for more than three hours after the scheduled time, continue with next scheduled dose and skip the missed dose.
Do not take a double dose to make up the missed dose.

Breastfeeding should de discontinued while on treatment with acalabrutinib and should not be resumed at least 2 weeks after the last dose of acalabrutinib.
Patients are advised to report to the emergency center if serious reactions such as severe bleeding, serious infection or difficulty in breathing occur.

What are the Drug Interactions of Acalabrutinib?

Many drugs can result in life-threatening interactions when taken with acalabrutinib and their co-administration with acalabrutinib should be avoided.

These include:
Anti-coagulants (e.g. warfarin)
Antifungal medicines (e.g. Itraconazole, ketoconazole, voriconazole)
Anti-viral medicines (e.g.Ribavirin, boceprevir, telaprevir)

Drugs like rifampicin reduce the blood levels of acalabrutinib, and can therefore reduce the effect of acalabrutinib.

The co-administration of proton pump inhibitors such as omeprazole, lansoprazole, pantoprazole or antacids or antiulcer drugs like ranitidine or famotidine with acalabrutinib should be avoided as the combination reduces the concentration of acalabrutinib. A gap of a minimum of two hours should be maintained when administered with antacids. Acalabrutinib should be taken a minimum of 2 hours before drugs like ranitidine or famotidine.

What are the storage conditions for Acalabrutinib?

Store acalabrutinib capsules at room temperature between 20C to 25C
Protect from excess heat and moisture
Keep away from the reach of children.

Last Updated : Jul 2018
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