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Cilamin 250 (Penicillamine) Drug Price and Information

Cilamin 250 is a chelating agent (remove heavy metals from the body), prescribed for Wilson disease (excess copper in the body), severe rheumatoid arthritis that has not responded to other treatments, and cystinuria (excess amino acids in the urine, which causes kidney stones). 

Cilamin 250

  Capsule
Panacea Biotec Ltd.
Generic : Penicillamine
 110.00
250mg
10 Capsules
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    Drug information on Cilamin 250 (Penicillamine) from Panacea Biotec Ltd.

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    Drug Name : Penicillamine

    Penicillamine(Cuprimine) generic Cilamin 250 is a chelating agent (remove heavy metals from the body), prescribed for Wilson disease (excess copper in the body), severe rheumatoid arthritis that has not responded to other treatments, and cystinuria (excess amino acids in the urine, which causes kidney stones).
    More Info about Penicillamine

    Trade Names for Penicillamine

    Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team on February, 2, 2017
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    Medical condition(s) for which Cilamin 250 may be prescribed


    Dosage & When it is to be taken (Indications)

    Oral- Wilson's disease- Adult: Initially, 1.5-2 g daily in divided doses. Maintenance dose: 0.75-1 g daily. Doses titrated to maintain urinary copper excretion >2 mg/day. Patients should receive pyridoxine supplementation 25 mg/day. Max: 750 mg/day in older adults.
    Child: 1 month-12 years: 2.5 mg/kg bid, increased every 1-2 weeks to 10 mg/kg bid. 12-18 years: 0.75-1 g bid, max: 2 g daily for 1 years; usual maintenance 0.75-1 g daily. Doses titrated to maintain urinary copper excretion >2 mg/day. Patients should receive pyridoxine supplementation 25 mg/day.
    Cystine calculi- Adult: 1-4 g daily in 4 divided doses. Usual dose: 2 g/day. If 4 equal doses are not possible, give largest dose at bedtime. Doses adjusted to limit cystine excretion to 100-200 mg/day (<100 mg/day with history of stone formation). Patients should receive pyridoxine supplementation 25 mg/day.
    Child: 1 month-12 years: 5-10 mg/kg bid, 12-18 years: 0.5-1.5 g bid. Doses adjusted to limit cystine excretion to 100-200 mg/day (<100 mg/day with history of stone formation). Patients should receive pyridoxine supplementation 25 mg/day.
    Lead poisoning Adult: 1-2 g daily in 3 divided doses. Continue treatment until urinary lead is stabilised at <500 mcg/day. Child: 20 mg/kg/day in 3 divided doses. Elderly: 20 mg/kg/day in 3 divided doses.
    Cystinuria Adult: 1-4 g daily in 4 divided doses. Usual dose: 2 g/day. If 4 equal doses are not possible, give largest dose at bedtime. Doses adjusted to limit cystine excretion to 100-200 mg/day (<100 mg/day with history of stone formation). Patients should receive pyridoxine supplementation 25 mg/day.
    Child: 1 month-12 years: 5-10 mg/kg bid, 12-18 years: 0.5-1.5 g bid.

    Side effects of Cilamin 250

    Central Nervous System: Peripheral sensory and motor nerve disease (including Guillain-Barré syndrome), psychic disturbances, mental disorders, agitation, anxiety.

    Skin: Hives, scaly inflammation of the skin, hair loss, mucocutaneous disease, detachment of the top layer of skin from the lower layers of the skin, increased skin friability, excessive wrinkling, development of small white papules at venipuncture(IV therapy) and surgical sites, yellow nail syndrome.

    Eye and ENT: Perception of sound within the human ear in the absence of corresponding external sound, inflammation of optic nerve, visual disturbances.

    Gastrointestinal: Loss of appetite, abdomen pain, nausea, vomiting, diarrhea, diminished taste perception, peptic ulcers, inflammation of pancreas, oral ulcers.

    Hormone: Inflammation of thyroid gland.

    Blood: Decrease in white blood cells, platelets, and red blood cells, increase in number of monocytes in blood.

    Liver: Drug induced liver disease.

    Musculoskeletal: Joint pains, chronic autoimmune neuromuscular disease, involuntary movements.

    Kidney: Protein in urine, blood in urine, kidney disorder, kidney failure.

    Respiratory: Allergic Inflammation of the alveoli, irreversible lung disease, progressive scarring of both lungs, bronchial asthma.

    Miscellaneous: Allergy, including generalized itching with early and late rashes, blistering; drug eruptions, autoimmune disease, vein inflammation, elevated body temperature, muscle inflammation, connective-tissue disease, increased size of breast, abnormal elastic tissue fibers, inflammatory destruction of blood vessels.

    How to use Cilamin 250?

    Should be taken on an empty stomach. (Take on an empty stomach 1 hr before or 2 hr after meals, & at least 1 hr apart from any other drug, food, milk, antacid, Zn- or Fe-containing prep.)

    When Should Cilamin 250 not be taken? (Contraindications)

    Contraindicated to pregnancy and breast feeding, patients with history of moderate to severe kidney problem, prior penicillamine induced bone marrow problem, severe allergic reactions.

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    Warnings and Precautions for Cilamin 250

    Wilson's disease and cyst in urine (25 mg/day) continued on a daily basis once instituted; kidney impairment; penicillin allergy;

    Monitor urine for protein in urine and haematuria (blood in urine), blood and platelet counts regularly.

    Withdraw permanently if decrease in the number of white blood cells or platelets occurs.

    Regularly monitor kidney and liver function (every 6 month).

    Monitor body temperature twice weekly during 1st month of therapy, then every 2 wk for 5 month, then monthly.

    Counsel patient to report sore throat, fever, infection, non-specific illness, unexplained bleeding or bruising, mouth ulcers or rashes.

    In cyst in urine, maintain adequate fluid intake (1 pint of fluid before bed and 1 pint of fluid during night).

    Caution should be exercised in patients who have had previous adverse reactions to gold.

    Other Precautions for Cilamin 250

    Penicillamine serum levels may be decreased if taken with food, take 1 hour before meals and at bedtime.

    Storage Conditions for Cilamin 250

    Oral: Store in tight, well closed containers.



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    For the above reasons, Medindia cannot be held liable for any action taken based on the information provided by its website. The purpose of this website is to provide initial guidance only and it does not intend to replace professional medical opinion in any manner whatsoever.

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