AstraZeneca Pharma India Ltd. Generic : Dinoprostone
213.00 0.5mg 30gm
Increased uterine contraction with or without fetal distress, rupture of the uterus
• Gastrointestinal : Nausea, vomiting, diarrhea, and abdominal pain.
• Miscellaneous: Fever, low blood pressure, increase in eye pressure, headache, breathing difficulty.
• Blood: An increased risk of postpartum disseminated intravascular coagulation.
Vaginal Dilatation of cervix, induction and augmentation of labor- As gel: 0.5mg, may repeat 6 hr later if needed up to a maximum of 1.5 mg/24 hour.
Labor induction- As gel: 1 mg, then 1 or 2 mg 6 hr later if neededup to a maximum of 3 mg. As pessary: 3 mg, then 3 mg 6-8 hour later if neededup to a maximum of 6 mg. Suppository: 20mg, inserted into vagina.
Pregnancy termination: It is injected outside the amniotic sac As 100 mcg/ml solution, 1 ml, followed by 1-2 ml at 2-hr intervals according to response.
It comes as a vaginal suppository and as a gel that is inserted into the vagina and solution for injection administered by a health professional. Patient should lie down after insertion of this medication.
It is contraindicated in patients allergic to prostaglandins, patients with heart, lung, kidney, liver disease or pelvic inflammatory disease.
• It may raise eye pressure hence should be used with caution in patients with glaucoma.
•Caution needed for patients with history of previous cesarean section, asthma; anemia; uterine surgery; diabetes; high or low blood pressure; placenta previa(condition where the placenta partly or completely covers the outlet of the uterus); a seizure disorder; previous multiple pregnancies; glaucoma or increased pressure in the eye; cephalopelvic disproportion (babies head or body is too large to fit through the mother's pelvis); previous difficult or traumatic deliveries; or unexplained vaginal bleeding.
Do not change your dose unless your doctor tells you to do so.
Cervical gel: Refrigerate at 2-8°C. Vaginal supp: Store in a freezer below -20°C. Vaginal insert: Store in a freezer between -20°C & -10°C.
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