Drug information on Xylistin (1 million iu) (Colistimethate Injection) from Cipla Limited

Medical Condition(s) for which Xylistin (1 million iu) may be prescribed

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•  Gastrointestinal: Gastrointestinal upset.

•  Central Nervous System: Tingling of extremities and tongue, slurred speech, dizziness and fainting.

•  Skin : Generalized itching, hives and rash.

•  Body as a Whole : Fever.

•  Respiratory : Respiratory disorder and shortness of breath.

•  Genitourinary : Kidney damage and decreased urine output.

PO- GI infections; Bowel sterilization- 1.5-3 million units 3 times/day.
IV/IM- GI infections; Bowel sterilization as colistimethate Na: 6 million units/day in 3 divided doses. Max: 6-million units/24 hour.
Inhalation- Adjunct to antimicrobial therapy in respiratory infections as colistimethate Na: 1-2 million units twice daily. Max: 2 million units 3 times/day for up to 3 month in frequent recurrent infections.

It comes as a syrup to take by mouth.

Hypersensitivity.

• Caution should be exercised in patients with history of preexisting kidney impairment, disorders of neuromuscular transmission, during pregnancy and lactation.

• Monitor liver enzyme level and Blood Urea Nitrogen level regularly while on treatment.

Avoid excess dosage and alcohol consumption.

Store reconstituted solution in refrigerator at 2°-8°C (36°-46°F) or between 20°-25°C