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Drug information on Aprotin (70 mg) (Aprotinin) from VHB Lifesciences Inc.

Aprotin (70 mg)   Injection VHB Lifesciences Inc. Generic : Aprotinin	1,482.00 1.4mg/1ml 50ml

Information Checked by Dhanalakshmi Chinnuswamy, Diploma in Pharmacy, MBA (Healthcare)

Further Checked by The Medindia Medical Review Team on Dec 14, 2010

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Bleeding Disorders

•  Body as a Whole: Fever, infection, chest pain, weakness, sepsis, death, multi-system organ failure, immune system disorder.

•  Heart: Low blood pressure, fast heart rate, heart attack and heart failure.

•  Gastrointestinal: Nausea, constipation, vomiting, liver failure, jaundice and diarrhea.

•  Blood: Anemia.

•  Metabolic: Increased liver enzyme level, high blood sugar, decreased potassium levels.

•  Musculoskeletal: Any event.

•  Central Nervous System: Confusion, agitation, anxiety and sleeplessness.

•  Respiratory: Lung disorder, pleural effusion, difficulty in breathing, increased cough, asthma and shortness of breath.

•  Skin: Rash, skin discolouration.

•  Genitourinary: Abnormal kidney function, urinary retention and urinary tract infection.

•  Potentially Fatal:: Fatal anaphylactic reactions.

The 1ml initial (test) dose should be administered intravenously at least 10 minutes before the loading dose.
Adult: IV- 5 lac KIU (Kallikrein in activator unit) initially, followed by 2 lac KIU every 4 hour.

It comes as a solution for injection, to be administered by a healthcare provider into the vein.

Hypersensitivity.

• Test dose is recommended to all patients to assess the risk of hypersensitivity.

• Caution should be exercised in patients with history of heart surgery, liver or kidney disease, allergy, during pregnancy and lactation.

• The loading dose should be given intravenously to patients in the supine position over a 20-30 minute period. Rapid intravenous administration can cause a transient fall in blood pressure.

• Pediatric use is not recommended. Patient may develop with increased risk of severe allergic reactions if it is administered within 12 months of previous use of this medication.

•

It should not be used in neonates and children.

Store at 2-25°C. Avoid freezing.