This medication is a bisphosphonate, primarily used for prevention and treatment of osteoporosis in men and postmenopausal women. It is also used for Paget's disease and osteoporosis caused by steroid treatment. It reduces the amount of calcium released from the bones into the blood.
Contraindicated in patients who are allergic to this drug, people with paralysis condition and during pregnancy and lactation.
IV- The recommended dose is 4mg/100m, over 15min; may be repeated after a week.
It comes as a solution for injection, administered by a healthcare provider.
• Caution should be exercised in patients with history of kidney disease, dehydration problem, asthma, during pregnancy and breastfeeding.
• Drink adequate fluids to avoid dehydration.
• Do routine oral examination in patients at risk of osteonecrosis of the jaws.
• Monitor serum electrolytes, calcium, phosphate and magnesium.
• Withhold treatment if there is worsening of kidney function.
• It may cause dizziness, do not drive a car or operate machinery while taking this medication.
• Most Common:
Fever, muscle pain, headache, joint pain, pain in extremity.
• Blood : Anemia.
• Metabolic : Dehydration and loss of appetite.
• Central Nervous System: Dizziness.
• Heart: Atrial fibrillation, vascular disorders and high blood pressure.
• Gastrointestinal: Nausea, diarrhea, vomiting and abdominal pain.
♦ • Musculoskeletal: Shoulder pain, neck pain, fractures, and muscle spasms.
• General : Fever, influenza-like illness, fatigue, chills, weakness, peripheral edema, uneasiness and chest pain.
Maintain proper level of calcium and Vitamin D. Patient may develop kidney impairment.
Injection: Store at 15-30°C (59-86°F). Normally stored by healthcare providers.
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