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General Information on Zoledronic Acid

Generic Name : Zoledronic Acid

Pronunciation : ZOE-le-DRON-ik AS-id

Latest prescription information about Zoledronic Acid. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y57.9 | Therapeutic Classification : Bone Enhancers

Trade Names/Brand Names of Zoledronic Acid

India : 

International : 

Reclast, Zometa, Aclasta

Why is Zoledronic Acid Prescribed? (Indications)

This medication is a bisphosphonate, primarily used for prevention and treatment of osteoporosis in men and postmenopausal women. It is also used for Paget's disease and osteoporosis caused by steroid treatment. It reduces the amount of calcium released from the bones into the blood. 

When should Zoledronic Acid not to be taken? (Contraindications)

Contraindicated in patients who are allergic to this drug, people with paralysis condition and during pregnancy and lactation.

What is the dosage of Zoledronic Acid?

IV- The recommended dose is 4mg/100m, over 15min; may be repeated after a week.

How should Zoledronic Acid be taken?

It comes as a solution for injection, administered by a healthcare provider.

What are the warnings and precautions for Zoledronic Acid?

Caution should be exercised in patients with history of kidney disease, dehydration problem, asthma, during pregnancy and breastfeeding.

Drink adequate fluids to avoid dehydration.

Do routine oral examination in patients at risk of osteonecrosis of the jaws.

Monitor serum electrolytes, calcium, phosphate and magnesium.

Withhold treatment if there is worsening of kidney function.

It may cause dizziness, do not drive a car or operate machinery while taking this medication.

What are the side effects of Zoledronic Acid?

  Most Common: Fever, muscle pain, headache, joint pain, pain in extremity.
  Blood : Anemia.
   Metabolic : Dehydration and loss of appetite.
  Central Nervous System: Dizziness.
  Heart: Atrial fibrillation, vascular disorders and high blood pressure.
  Gastrointestinal: Nausea, diarrhea, vomiting and abdominal pain.
   Musculoskeletal: Shoulder pain, neck pain, fractures, and muscle spasms.
   General : Fever, influenza-like illness, fatigue, chills, weakness, peripheral edema, uneasiness and chest pain.

What are the other precautions for Zoledronic Acid?

Maintain proper level of calcium and Vitamin D. Patient may develop kidney impairment.

What are the storage conditions for Zoledronic Acid?

Injection: Store at 15-30C (59-86F). Normally stored by healthcare providers.

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