Urokinase - Indications, Dosage, Side Effects and Precautions

Last Updated on August 11, 2022
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Information about Urokinase

Generic Name : Urokinase
Up-to-date prescription details regarding Urokinase are provided here.
Pronunciation : ure-oh-KYE-nase
Learn the correct pronunciation of the Urokinase, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.
ICD Code : Y43.6 | Therapeutic Classification : Enzymes

Why is Urokinase Prescribed? (Indications)

This medication is an enzyme (thrombolytic agent), prescribed for deep vein thrombosis, heart attack, pulmonary embolism and peripheral vascular occlusion. It dissolves blood clots. 

When should Urokinase not be taken? (Contraindications)

Contraindicated in patients with active internal bleeding; history of stroke; recent (within 2 month) trauma including surgery on brain and spinal cord; aneurysm or tumor within the brain; known bleeding diathesis; severe uncontrolled high blood pressure, allergy to the drug.

What is the dosage of Urokinase?

Adult: IV- Deep vein thrombosis; Pulmonary embolism: Initial: 4,400 u/kg over 10 minutes, then 4,400 u/kg/hr for 12-24 hour (deep vein thrombosis) or 12 hour (pulmonary embolism).
Peripheral arterial thromboembolism: As 2,000 u/ml solution: Infuse into a clot via a catheter at a rate of 4,000 u/min for 2 hour.
Heart Attack: 2.5 lac IU over 10 minutes followed by 5 lac IU over the next 1 hour.

How should Urokinase be taken?

It comes as a solution for injection to be injected by a healthcare provider into the vein.

What are the warnings and precautions for Urokinase?

• Any vascular punctures or invasive procedures should be avoided.

• Caution needed for patients with history of peptic ulcer disease, pre-existing bleeding disorders, high blood pressure, heart infection, recent biopsy or surgery, recent injury, any allergies.

• Use extra caution to avoid injury and trauma. Use with caution in patients with liver or kidney disease, coagulation defects, brain disease, damage to the retina due to diabetes or any other condition in which bleeding could be dangerous, pregnancy or after recent surgery, childbirth or trauma.

• Monitor for reperfusion heart rate when used in heart attack.

• It may increase the risk of cerebral bleeding.

What are the side effects of Urokinase?

  Most Common: Severe bleeding.
  Heart : Heart attack, recurrent blood clot in lungs, stroke.
  Blood: Decreased red blood cells and platelets.
  Miscellaneous: Excess sweating.
  Potentially Fatal: Severe bleeding, severe allergic reactions, cholesterol embolization. Other side effects such as heart arrest and irregular heart rate have also been seen in patients taking urokinase.

What are the other precautions for Urokinase?

Blood tests including hematocrit, platelet count and activated partial thromboplastin time should be checked.

What are the storage conditions for Urokinase?

Injection: Store below 25°C. Store it in room temperature, and in an airtight container.

Schedule : H
Prescription drugs - Drugs to be sold only under the prescription of a Registered Medical Practitioner.
Last Updated : August 11, 2022

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