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General Information on Tolcapone

Generic Name : Tolcapone

Pronunciation : TOLE-ka-pone

Latest prescription information about Tolcapone. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y46.7 | Therapeutic Classification : Antiparkinson Agents

Trade Names/Brand Names of Tolcapone

International- Tasmar.

Why is Tolcapone Prescribed? (Indications)

This medication is a catechol-O-methyl transferase (COMT) inhibitor, prescribed for Parkinson's disease along with levodopa/carbidopa.  It prolongs the anti-Parkinson's effect of levodopa.

When should Tolcapone not to be taken? (Contraindications)

Contraindicated in patients with rhabdomyolysis (condition in which skeletal muscle cells break down), liver disease and hypersensitivity.

What is the dosage of Tolcapone?

Initial: The recommended dose is 100 mg, three times per day.

How should Tolcapone be taken?

It comes as a tablet to take by mouth, as directed by your physician.

What are the warnings and precautions for Tolcapone?

Caution should be exercised in patients with history of heart or kidney disease, elderly, during pregnancy and breastfeeding.

It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.

Avoid alcohol consumption.

What are the side effects of Tolcapone?

  Most Common: Movement disorder, nausea, sleep disorder, involuntary movements, excessive dreaming, loss of appetite, muscular cramps, orthostatic complaints, drowsiness, diarrhea, confusion, dizziness, headache, hallucinations, vomiting, constipation, fatigue, upper respiratory tract infection, falling, increased sweating, urinary tract infection, dry mouth, abdominal pain and urine discoloration.
  Central Nervous System: Depression, sensory loss, tremor, speech disorder, unsteadiness and emotional lability.
  Gastrointestinal: Tooth disorder.
  Body as a Whole: Flank pain, accidental injury, abdominal pain and infection.
  Heart: Palpitations.
  Musculoskeletal: Muscle pain.
  Genitourinary: Urinary incontinence and impotence.
  Respiratory: Inflammation of bronchus and pharynx.
  Eye and ENT: Ringing in the ear.

What are the other precautions for Tolcapone?

Avoid excess dosage.

What are the storage conditions for Tolcapone?

Store it at controlled room temperature (20 to 25C).

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