This medication is a catechol-O-methyl transferase (COMT) inhibitor, prescribed for Parkinson's disease along with levodopa/carbidopa. It prolongs the anti-Parkinson's effect of levodopa.
Contraindicated in patients with rhabdomyolysis (condition in which skeletal muscle cells break down), liver disease and hypersensitivity.
Initial: The recommended dose is 100 mg, three times per day.
It comes as a tablet to take by mouth, as directed by your physician.
• Caution should be exercised in patients with history of heart or kidney disease, elderly, during pregnancy and breastfeeding.
• It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.
• Avoid alcohol consumption.
• Most Common:
Movement disorder, nausea, sleep disorder, involuntary movements, excessive dreaming, loss of appetite, muscular cramps, orthostatic complaints, drowsiness, diarrhea, confusion, dizziness, headache, hallucinations, vomiting, constipation, fatigue, upper respiratory tract infection, falling, increased sweating, urinary tract infection, dry mouth, abdominal pain and urine discoloration.
• Central Nervous System: Depression, sensory loss, tremor, speech disorder, unsteadiness and emotional lability.
• Gastrointestinal: Tooth disorder.
• Body as a Whole: Flank pain, accidental injury, abdominal pain and infection.
• Heart: Palpitations.
• Musculoskeletal: Muscle pain.
• Genitourinary: Urinary incontinence and impotence.
• Respiratory: Inflammation of bronchus and pharynx.
• Eye and ENT: Ringing in the ear.
Avoid excess dosage.
Store it at controlled room temperature (20° to 25°C).
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