Vijayaganesh Kasinathan
Written & Compiled by Pharmacist Vijayaganesh Kasinathan, B.Pharm, M.Pharm
Last Updated on May 04, 2018
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Last Updated : 5/4/2018

General Information on Tildrakizumab-asmn

Generic Name : Tildrakizumab-asmn

Pronunciation :  til-dra-KIZ-eu-mab-asmn

Latest prescription information about Tildrakizumab-asmn. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Monoclonal antibodies

Trade Names/Brand Names of Tildrakizumab-asmn

Ilumya

Overview of Tildrakizumab-asmn

Tildrakizumab-asmn injection was approved by FDA to treat adults with immunologically mediated inflammatory disorders such as moderate to severe plaque psoriasis.

Why is Tildrakizumab-asmn Prescribed? (Indications)

Tildrakizumab-asmn is an interleukin-23 antagonist which is prescribed for treating adults suffering from moderate to severe plaque psoriasis who may benefit with systemic therapy or phototherapy.

Tildrakizumab-asmn is a monoclonal antibody which works by binding to interleukin-23 and blocking it from attaching to its receptor; it thus reduces the release of cytokines and chemokines which are responsible for causing inflammation. 

When should Tildrakizumab-asmn not to be taken? (Contraindications)

Tildrakizumab-asmn should not be used in patients

Allergic to tildrakizumab-asmn
Pregnant and breastfeeding
With any active infection (e.g., tuberculosis)
With a low immune system
Under 18 years of age

What is the dosage of Tildrakizumab-asmn?

The recommended adult dose is 100 mg to be given at week 0 and at week 4 followed by a dose every 12 weeks after that.

How should Tildrakizumab-asmn be taken?

Tildrakizumab-asmn is available as an injection or a pre-filled syringe which should be administered by a healthcare provider subcutaneously (just under the skin).
Pre-filled syringes should be used only once and discarded after that.

What are the warnings and precautions for Tildrakizumab-asmn?

Patients should be evaluated for the presence of tuberculosis (TB) infection before starting treatment with tildrakizumab-asmn. If the patient is suspected of TB infection, the treatment should not be initiated.
Patients should be advised to consult the physician if any signs or symptoms of acute or chronic infections are observed, as tildrakizumab-asmn can increase the severity of the infections. Discontinue tildrakizumab-asmn therapy until the infection resolves.

Patients can develop neutralizing antibodies to tildrakizumab while taking tildrakizumab-asmn as a long-term therapy resulting in decreased serum concentration of tildrakizumab-asmn or treatment failure.

What are the side effects of Tildrakizumab-asmn?

Diarrhea
Upper respiratory tract infections
Nasopharyngitis
Urticaria
Pruritus
Pain, swelling, redness or bruising at the injection site

What are the other precautions for Tildrakizumab-asmn?

Before administration, place the tildrakizumab-asmn injection out of the refrigerator for 30 minutes to come to room temperature.
Check the injection for the presence of any particulate matter or discoloration; if so discard the medication and use a fresh one.
The injection sites are thighs, abdomen, or upper arm. Never inject inside the 2-inch circumference around the navel.
Do not inject onto scars, stretch mark areas, psoriasis affected sites, tender or bruised skin.

What are the Drug Interactions of Tildrakizumab-asmn?

The concentration of dextromethorphan was found to increase when administered together with tildrakizumab-asmn 200 mg and therefore should be avoided.
Do not take live vaccines such as MMR, Herpes zoster, or yellow fever vaccine while on treatment with tildrakizumab-asmn as it results in severe infection.

What are the storage conditions for Tildrakizumab-asmn?

Tildrakizumab-asmn injection should be stored in the refrigerator at 2C to 8C.
Should be kept in the original carton and protected from light.
Do not shake or freeze.
Tildrakizumab-asmn can be stored at room temperature (below 25C) for a maximum of 30 days but should be discarded after 30 days if not used.
Do not place tildrakizumab-asmn injection in the refrigerator if it has already been kept at room temperature.

Last Updated : 5/4/2018

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