Pyrimethamine- Sulfadoxine - Indications, Dosage, Side Effects and Precautions


Information about Pyrimethamine- Sulfadoxine

Generic Name : Pyrimethamine- Sulfadoxine
Up-to-date prescription details regarding Pyrimethamine- Sulfadoxine are provided here.

Pronunciation : peer-i-METH-a-meen - sul-fa-DOX-een

Learn the correct pronunciation of the Pyrimethamine- Sulfadoxine, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.

ICD Code : Y41.2 Therapeutic Classification : Anti- Malarials

Trade Names/Brand Names of Pyrimethamine- Sulfadoxine

India :

International :


Why is Pyrimethamine- Sulfadoxine Prescribed? (Indications)

This medication is an antimalarial agent, prescribed for treatment of falciparum malaria, resistant to chloroquine. It blocks the formation of folinic acid within the malaria organism, which kills the parasite.

When should Pyrimethamine- Sulfadoxine not be taken? (Contraindications)

Contraindicated in patients with severe kidney or liver failure, blood disorder, hypersensitivity to components, megaloblastic anemia due to folic acid deficiency, pregnancy at term and during lactation, infants ≤ 2 month old.

What is the dosage of Pyrimethamine- Sulfadoxine?

PO- The recommended single dose is 3 tabs (sulfadoxine/ pyrimethamine 500 mg /25 mg), take next dose after 7 days, if needed.

How should Pyrimethamine- Sulfadoxine be taken?

It comes as a tablet to take by mouth, after food.

What are the warnings and precautions for Pyrimethamine- Sulfadoxine?

•Caution should be exercised in patients with history of liver or kidney failure, folic acid deficiency, severe allergy or bronchial asthma, G6PD deficiency, pregnancy.

• Take with plenty of water to prevent crystal or stone formation in the urinary tract.

Avoid excessive exposure to sun.

• Regular laboratory testing of blood counts, urine and liver functions should be carried out.

• Take with food to minimize GI effects (e.g. anorexia and vomiting).

What are the side effects of Pyrimethamine- Sulfadoxine?

Blood- Decrease in white blood cells, bone marrow depression, decrease in platelets, anemia, bruising, poor blood clot, methemoglobinemia, and increase in eosinophils.
Allergic Reactions- Rash, itching, swelling, dizziness, trouble breathing.
Skin- Severe allergic reactions, hair loss.
Eye- Photosensitivity, swelling in the eye.
Gastrointestinal - Inflammation of tongue, mouth infection, nausea, vomiting, abdominal pains, diarrhea, inflammation of liver or pancreas, feeling of fullness, and transient rise of liver enzymes.
Central Nervous System - Depression, headache, hallucinations, fatigue, nervousness, fainting. Sleeplessness, inflammation of nerves, involuntary movements, emotion, muscle weakness.
Respiratory- Pulmonary infiltrates resembling eosinophilic or lung inflammation.
Genitourinary- Kidney failure, interstitial nephritis, decreased urination, and crystals in urine.
Miscellaneous - Drug fever, chills, and LE phenomenon have occurred.

What are the other precautions for Pyrimethamine- Sulfadoxine?

Take full course of treatment.
If there is no improvement in your health condition or if they become worse consult with your doctor.

What are the storage conditions for Pyrimethamine- Sulfadoxine?

Store it at room temperature, (20 and 25 degrees C). Store it in an airtight container, and keep away from children and pets.
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