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General Information on Proguanil

Generic Name : Proguanil

Pronunciation : proe-GWAHN-il

Latest prescription information about Proguanil. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y41.2 | Therapeutic Classification : Anti- Malarials

Trade Names/Brand Names of Proguanil

India : 

International : 

Malarone- Atovaquone +Proguanil

Why is Proguanil Prescribed? (Indications)

This medication is an antiprotozoal and antimalarial, prescribed for prevention of malaria, treatment of malaria. It prevents the development of malaria parasites.  

When should Proguanil not to be taken? (Contraindications)

Contraindicated in patients with hypersensitivity, severe kidney failure.

What is the dosage of Proguanil?

Adult: PO- Malaria prophylaxis- 200 mg/day with chloroquine or 100 mg/day with atovaquone. Start 1 week before exposure to malaria or 1-2 days prior to travel. Continue throughout exposure and for at least 4 week (or 1 week if given with atovaquone) after leaving a malaria-infested area.

How should Proguanil be taken?

It comes as a tablet to take by mouth (orally), with food.

What are the warnings and precautions for Proguanil?

It may not work as well if you have severe or persistent vomiting or diarrhea.

It may make you drowsy. Do not drive a car or operate machinery while taking this medication.

Caution needed for patients with history of kidney disease, pregnancy, breast feeding, elderly, and children.

If you experience with vomiting within one hour after taking this medication, take another dose.

What are the side effects of Proguanil?

  Most Common in adult: Abdominal pain, nausea, vomiting, headache, diarrhea, weakness, loss of appetite, and dizziness.
  Children: Vomiting, and itching.
  Kidney: Blood in urine.
  Blood : Abnormally decrease in white blood cells, and rarely anemia. Decrease in all types of blood cells.
  Allergic reactions: Allergic reactions including rapid swelling, hives, rare cases of life-threatening allergies, and inflammation of blood vessels.
  Central Nervous System : Rarely seizures and hallucinations.
  Gastrointestinal : Mouth ulcer.
  Liver: Elevated liver function tests and rare cases of liver inflammation.
  Skin : Photosensitivity, rash, and rare cases of erythema multiforme and Stevens-Johnson syndrome.

What are the other precautions for Proguanil?

Avoid abrupt withdrawal.

What are the storage conditions for Proguanil?

Store it in an airtight container; keep away from children and pets.

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