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Mirtazapine - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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Information about Mirtazapine

Generic Name : Mirtazapine
Pronunciation : mihr-TAZZ-uh-peen
Latest prescription information about Mirtazapine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y49.2 | Therapeutic Classification : Psychotherapeutics

Trade Names/Brand Names of Mirtazapine

India : 


International : 


Why is Mirtazapine Prescribed? (Indications)

This medication is an antidepressant, prescribed for depression. It alters the activity of certain chemicals in the brain to maintain mental balance. 

When should Mirtazapine not be taken? (Contraindications)

Hypersensitivity to any component of the product; concomitant use with MAOInhibitors.

What is the dosage of Mirtazapine?

Oral: The recommended starting dose is 15mg/day administered in a single dose; if needed increase it as per your doctor’s advice. The maximum dose is 45 mg/day, in 2 divided doses.

How should Mirtazapine be taken?

It comes as a tablet and as a disintegrating tablet to take by mouth. It is usually taken once a day at bedtime, with or without food.

What are the warnings and precautions for Mirtazapine?

• Avoid in unstable cases, epilepsy or history of seizures.

• Caution should be exercised in patients with history of liver or kidney damage, heart diseases, recent sudden heart attack, low blood pressure, diabetes, psychoses, and history of bipolar disorder, elderly, pregnancy and breastfeeding.

• Stop treatment if jaundice, urination disturbances, angle-closure glaucoma, raised intraocular pressure develops.

• Monitor patient for signs of bone marrow depression and suicidal tendency.

• It may cause drowsiness, dizziness or impaired vision, do not drive a car or operate machinery while taking this medication.

What are the side effects of Mirtazapine?

  Heart: High blood pressure, palpitations, postural hypotension and dilation of the blood vessels.
  Central Nervous System: Drowsiness, loss of strength, dizziness, abnormal dreams, abnormal thinking, confusion, tremor, agitation, amnesia, anxiety, depression, headache, abnormal movements, and suicidal tendencies.
  Skin: Itching and rash.
  Gastrointestinal: Dry mouth, constipation, nausea, abdominal pain, acute abdominal syndrome, loss of appetite, diarrhea, impaired digestion, flatulence and vomiting.
  Genitourinary: Urinary frequency, sexual dysfunction and urinary tract infection.
  Blood: Decrease in white blood cells.
  Metabolic:Increased appetite, weight gain, peripheral edema and thirst.
  Musculoskeletal: Back pain, muscle pain, joint pain and muscle weakness.
  Respiratory: Shortness of breath, increased cough and sinusitis.
  Miscellaneous: Flu syndrome, poor or indistinct vision, inflammation of pharynx, rhinitis, taste perversion and ringing the ears.

What are the other precautions for Mirtazapine?

Avoid abrupt withdrawal.

What are the storage conditions for Mirtazapine?

Oral: Store it at 15-30°C. Protect from light and moisture.
Learn more about Mirtazapine's interaction with Food, Herbs and Alcohol

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