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Isoniazid - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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Information about Isoniazid

Generic Name : Isoniazid
Pronunciation : eye soe nye' a zid
Latest prescription information about Isoniazid. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y41.1 | Therapeutic Classification : Anti- Tuberculosis

Trade Names/Brand Names of Isoniazid

India : 


International : 

Tubizid, Nydrazid

Why is Isoniazid Prescribed? (Indications)

This medication is an antibiotic agent, prescribed for tuberculosis (TB) either alone or with other medications.  It works by killing TB organisms.


When should Isoniazid not be taken? (Contraindications)

Contraindicated in patients with severe liver disease, liver damage due to previous administration of this medication and hypersensitivity.

What is the dosage of Isoniazid?

Adults: 5mg/kg up to 300 mg daily in a single dose; or 15 mg/kg up to 900 mg/day, two or three times/week.
Children: 10-15 mg/kg up to 300 mg daily in a single dose; or 20-40 mg/kg up to 900 mg/day, two or three times/week.

How should Isoniazid be taken?

It comes as a tablet and liquid to take by mouth, on an empty stomach.

What are the warnings and precautions for Isoniazid?

• Caution should be exercised in patients with history of diabetes, nerve problems (because of the increased incidence of peripheral neuropathy with Isoniazid), kidney, HIV, any allergy, who are taking other medications, during pregnancy and breastfeeding.

• Avoid alcohol consumption.

• Avoid consuming tyramine containing food items such as cheese, red wine, beer, certain meats and sausages, liver, sour cream. Otherwise it may cause high blood pressure.

• Monitor liver function and blood sugar level regularly while taking this medication.

What are the side effects of Isoniazid?

   Severe Effect : Liver damage.
   Central Nervous System : Brain damage.
   Gastrointestinal : Nausea, vomiting and stomach distress.
   Blood : Anemia, decrease in platelets and eosinophilia.
   Hypersensitivity : Fever and skin eruptions.

What are the other precautions for Isoniazid?

Avoid excess dosage.

What are the storage conditions for Isoniazid?

Store it at room temperature, away from light and excess heat.
Do not allow the liquid to freeze.

Schedule : H
Prescription drugs - Drugs to be sold only under the prescription of a Registered Medical Practitioner.
Learn more about Isoniazid's interaction with Food, Herbs, Alcohol and Caffeine

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Santosh Panda, India

I want to download the antimycobacterial activity of some oxadiazoles,thiadiazoles,mannich bases

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