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Epoprostenol - Indications, Dosage, Side Effects and Precautions

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Information about Epoprostenol

Generic Name : Epoprostenol
Up-to-date prescription details regarding Epoprostenol are provided here.

Pronunciation : E-poe-PROST-e-nol

Learn the correct pronunciation of the Epoprostenol, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.


ICD Code : Y52.7 Therapeutic Classification : Anti- Hypertensives

Trade Names/Brand Names of Epoprostenol

International :


Flolan and Veletri

Why is Epoprostenol Prescribed? (Indications)

This medication is a prostaglandin, prescribed for pulmonary arterial hypertension. The medication relaxes blood vessels.

When should Epoprostenol not be taken? (Contraindications)

Contraindicated in people with congestive heart failure, lung swelling and hypersensitivity.

What is the dosage of Epoprostenol?

IV- The initial recommended dose is 2 mg/kg/min and increased in increments of 2 mg/kg/min every 15 minutes.

How should Epoprostenol be taken?

It comes as a solution for injection to be administered by a healthcare provider.

What are the warnings and precautions for Epoprostenol?

• Caution should be exercised in patients with history of bleeding problem, heart failure, liver or kidney, blood disorders, during pregnancy and breastfeeding.

• It may cause dizziness, drowsiness, and lightheadedness, do not drive a car or operate machinery and get up slowly from bed while taking this medication.

What are the side effects of Epoprostenol?

Most Common- Chest pain, anxiety, dizziness, slow or fast heart rate, difficulty in breathing, abdominal pain and musculoskeletal pain.
General- Weakness, fever, chills, flushing and flu-like symptoms.
Heart- Paleness, bluish color of the skin, palpitations, stroke, shock, bleeding, low blood pressure and heart attack.
Gastrointestinal- Loss of appetite, excess fluid, constipation, nausea, vomiting and flatulence.
Metabolic- Swelling in the leg, decreased potassium level in blood and weight loss/gain.
Musculoskeletal- Joint/bone/jaw pain.
Central Nervous System- Confusion, convulsion, depression, sleeplessness and headache.
Respiratory- Increased cough, nosebleed, excess fluid and inflammation of sinus.
Skin- Itching, rash, sweating, skin ulcer and hives.
Eye- Lazy eye and vision abnormality.
Genitourinary- Urinary tract infection and blood in urine.

What are the other precautions for Epoprostenol?

Avoid alcohol consumption.

What are the storage conditions for Epoprostenol?

Store reconstituted solutions in refrigerator at 2° to 8°C; avoid exposure to sunlight.
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