This medication is catechol-o-methyltransferase (COMT) inhibitor, used as an adjunct to levodopa/carbidopa to treat patients with idiopathic Parkinson‘s disease. It is used during the later stages when the patient does not respond well to levodopa/carbidopa. It increases the levels of levodopa/carbidopa in the brain, enhancing its effectiveness.
PO: The recommended dose is 200 mg with each levodopa/carbidopa up to a maximum of 1600 mg/day.
It comes as a tablet to take by mouth.
• It may cause dizziness, lightheadedness, or fainting; do not drive a car or operate machinery, while taking this medication.
• Avoid alcohol consumption.
• It may lead to an increase in involuntary movements.
• Caution needed during pregnancy and breastfeeding.
• Most Common:
Diarrhea, movement disorder, nausea, abdominal pain.
• Skin : Sweating increased
• Central Nervous System : Involuntary movements, increased or decreased movements, dizziness, anxiety, drowsiness, agitation, and worsening of condition.
• ENT: Taste perversion
• Gastrointestinal : Nausea, diarrhea, abdominal pain, constipation, vomiting, dry mouth, indigestion, flatulence, gastritis.
• Respiratory: Difficulty in breathing.
• Blood: Easy bruising
• Genitourinary: Urine discoloration
• Body as a whole: Back pain, fatigue, weakness
• Miscellaneous: Bacterial infection.
Stop this medication if unwanted symptoms developed.
Store it at room temperature and in airtight container. Keep away from children
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