Vijayaganesh Kasinathan
Written & Compiled by Pharmacist Vijayaganesh Kasinathan, B.Pharm, M.Pharm
Dr. Simi Paknikar
Medically Reviewed by Dr. Simi Paknikar, MD
Last Updated on Sep 23, 2017
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General Information on Edaravone

Generic Name : Edaravone

Pronunciation : e-DAR-a-vone

Latest prescription information about Edaravone. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Antioxidants

Trade Names/Brand Names of Edaravone

Overview of Edaravone

Edaravone is used in amyotrophic lateral sclerosis (ALS) or Lou Gehrig’s disease, a motor neuron disease.

Why is Edaravone Prescribed? (Indications)

Edaravone is prescribed for treating amyotrophic lateral sclerosis (ALS), a motor neuron disease or Lou Gehrig’s disease that causes the death of the nerve cells responsible for voluntary muscle contraction. This causes the muscles to become weak and leads to paralysis.
The exact mechanism of action of edaravone is not known. It probably works as an antioxidant, that is, it slows down the rate of nerve damage by reducing the oxidative stress. 

When should Edaravone not to be taken? (Contraindications)

Edaravone is contraindicated in patients who develop an allergic reaction, especially anaphylactic reaction which can be life threatening.

What is the dosage of Edaravone?

• The recommended dosage is 60mg administered as an intravenous infusion administered slowly over an hour as per the following schedule:
Initial cycle: Daily dosing for first 14 days followed by a gap of 14 days
Subsequent cycle: Daily dosing for 10 out of 14 days followed by a gap of 14 days in a 28-day cycle.

How should Edaravone be taken?

Edaravone comes as an infusion which is to be administered intravenously from a single dose polypropylene bag containing 30mg of edaravone in 100ml of clear, colorless aqueous solution.

What are the warnings and precautions for Edaravone?

• Emergency medical help is needed when a severe allergic reaction occurs with symptoms of itching, wheezing, and swelling of face, lips, tongue or throat.
• It should be used with caution in asthmatic patients as it contains sodium bisulfite, and asthmatic patients often exhibit sulfite sensitivity

What are the side effects of Edaravone?

  General: Gait disturbances, headache, presence of sugar in the urine (glycosuria)
  Allergic reactions: Severe allergic reactions including anaphylactic reactions can occur. The sulphite content can also cause an allergic reaction, especially in patients with asthma. Allergic reactions may consist of skin rashes, wheezing, difficulty with breathing, swelling around the throat and a severe fall in blood pressure (shock)
  Skin: Skin rashes, eczema, fungal (tinea) infection, bruising

What are the other precautions for Edaravone?

Women are advised to inform the doctor if they are pregnant or breastfeeding or planning a pregnancy before starting the medication.

What are the Drug Interactions of Edaravone?

Not known

What are the storage conditions for Edaravone?

• Store at a temperature of below 25°C. To be protected from light.
• Store in the overwrapped secondary packaging of polyvinyl alcohol provided with the drug to protect from oxygen degradation until it is used.
• It should not be used if the oxygen indicator provided with the packing has turned blue or purple.
• The opened package should be used within 24 hours of opening.

Last Updated : 9/23/2017

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