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General Information on Drotrecogin Alfa

Generic Name : Drotrecogin Alfa

Pronunciation : droe-tre-KOE-gin AL-fa

Latest prescription information about Drotrecogin Alfa. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y44.2 | Therapeutic Classification : Anticoagulants / Antithrombotics

Trade Names/Brand Names of Drotrecogin Alfa

India : 

International : 

Xigris Vial

Why is Drotrecogin Alfa Prescribed? (Indications)

This medication is a recombinant form of human activated protein C, prescribed for life threatening bacterial infections like severe sepsis (sepsis combined with organ malfunction). 

When should Drotrecogin Alfa not to be taken? (Contraindications)

Contraindicated in patients with high risk of intrinsic bleeding, stroke, epidural catheter, trauma, brain tumor and known hypersensitivity.

What is the dosage of Drotrecogin Alfa?

Adults-Infuse intravenously at 24 mcg/kg/hr (based on actual body weight) for a total duration of 96 hours.

How should Drotrecogin Alfa be taken?

It comes as a solution to be injected by a doctor or hospital staff.

What are the warnings and precautions for Drotrecogin Alfa?

It may cause severe bleeding, lie down in the bed during the treatment.

Monitor complete blood count, liver and kidney functions regularly while taking this medication.

Caution needed for patients with history of kidney disease, liver disease, HIV, organ transplants, stroke, head or spinal surgeries, ulcers, low platelet count, pregnancy, breastfeeding and any form of allergies.

What are the side effects of Drotrecogin Alfa?

  Most Common: High risk of bleeding in gastrointestinal tract, abdominal tract, brain (hemorrhagic stroke), skin and chest cavity.
  Blood: Decrease in the platelet count.
  Genitourinary: Renal failure, blood in urine.

What are the other precautions for Drotrecogin Alfa?

Take full course of treatment.

What are the storage conditions for Drotrecogin Alfa?

Store it in refrigerator at 2-8C, and in an airtight container. Do not freeze it.

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