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General Information on Decitabine

Generic Name : Decitabine

Pronunciation : dee-SYE-ta-been

Latest prescription information about Decitabine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y43.3 | Therapeutic Classification : Chemotherapy

Trade Names/Brand Names of Decitabine

International- Dacogen.

Why is Decitabine Prescribed? (Indications)

This medication is a nucleoside analog, prescribed for myelodysplastic syndromes (MDS). It blocks cell growth in the body.

When should Decitabine not to be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Decitabine?

IV- The recommended dose is 5 mg/mē by continuous infusion over 3 hours repeated every 8 hours for 3 days. This cycle should be repeated every 6 weeks.

How should Decitabine be taken?

It comes as a solution for injection to be administered by a healthcare provider into the vein.

What are the warnings and precautions for Decitabine?

• Caution should be exercised in patients with history of liver or kidney disease, any allergy, who are taking other medications, children, during pregnancy and breastfeeding.

• It may cause dizziness or blurred vision, do not drive a car or operate machinery while taking this medication.

• Avoid contact with people who have infections.

• It may raise blood sugar level with increased thirst, drowsiness, or confusion. If it is so consult with your doctor immediately.

• It may reduce platelet counts; avoid injury or bruising.

What are the side effects of Decitabine?

•   Most Common : Anemia, decrease in white blood cells and platelets, fatigue, fever, nausea, cough, constipation, diarrhea, and sugar.
•   Blood : Inflammation of lymph nodes.
•   Heart : Lung swelling, low blood pressure and blood clot events.
•   Eye : Blurred vision.
•   Gastrointestinal : Vomiting, abdominal pain, mouth ulcer, indigestion, gum bleeding, piles, loose stools, tongue ulceration, difficulty in swallowing, lip ulceration, abdominal distension, abdominal pain upper, gastro-esophageal reflux disease and burning mouth syndrome (BMS).
•   General : Swelling in the extremities, rigors, pain, lethargy, tenderness, fall, chest discomfort, uneasiness, injection site swelling, pain and irritation.
•   Liver : Increase in liver enzyme levels.
•   Injury : Transfusion reaction and abrasion.
•   Metabolic : Loss of appetite, dehydration and decrease in blood minerals.
•   Musculoskeletal : Joint pain, pain in limb, back pain, chest wall pain and muscle pain.
•   Central Nervous system : Headache, dizziness, sensory loss, sleeplessness, confusion, and anxiety.
•   Genitourinary : Painful urination, urinary frequency and urinary tract infection.
•   Respiratory : Cough, crackles lung, decreased breath sounds and oxygen.
•   Skin : Blister, redness, rash, lesion, itching, hair loss, hives and swelling in the face.

What are the other precautions for Decitabine?

Avoid excess dosage.

What are the storage conditions for Decitabine?

Store it in room temperature.

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