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Dasatinib - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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General Information on Dasatinib

Generic Name : Dasatinib
Pronunciation : da sa' ti nib
Latest prescription information about Dasatinib. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y43.3 | Therapeutic Classification : Chemotherapy
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Trade Names/Brand Names of Dasatinib

India : 

International : 

Sprycel Tab
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Why is Dasatinib Prescribed? (Indications)

This medication is prescribed for blood cancer(Chronic Myeloid Leukemia). It is a protein-tyrosinekinase inhibitor. It blocks the action of an abnormal protein that signals cancer cells to multiply.  

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When should Dasatinib not be taken? (Contraindications)

Known hypersensitivity.

What is the dosage of Dasatinib?

Chronic Phase CML Adults- Start with 100 mg orally once daily in the morning or evening. May increase dosage to 140 mg once daily in patients who do not achieve a hematologic or cytogenetic response.
Accelerated Phase CML, Myeloid or Lymphoid Blast Phase CML, or Ph+ ALL Adults- Start with 140 mg once daily in the morning or evening. May escalate dosage to 180 mg once daily in patients who do not achieve a hematologic or cytogenetic response.

How should Dasatinib be taken?

It comes as a tablet to take by mouth. It is usually taken twice a day, in the morning and evening, with or without food.

What are the warnings and precautions for Dasatinib?

• Men should use condom to avoid pregnancy when having sex with partner.

• It may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths.

• Lab tests, including liver and kidney function, blood electrolytes, and blood counts, may be performed while using this medication.

• Caution should be exercised patients who had lactose intolerance, low levels of potassium or magnesium in your blood, long QT syndrome (a heart condition that may cause dizziness, fainting, or irregular heartbeat), or liver or heart disease, pregnancy and breast feeding.

What are the side effects of Dasatinib?

  Central Nervous System: Headache, dizziness, confusion, depression, mood or mental changes, signs of bleeding in the brain, seizures.
  Heart: Chest pain, irregular heartbeat, shortness of breath.
  Gastrointestinal: Nausea, vomiting, sores in the mouth, severe or persistent diarrhea, blood in the vomit.
  Skin: Skin rash, peeling skin, red, swollen, or blistered skin.
  Miscellaneous: Muscle pain, tiredness, weight loss, change in the amount of urine, dry cough, fainting, irritation or, ringing in the ears.

What are the other precautions for Dasatinib?

Use with caution in patients receiving anticoagulants or medications that may inhibit platelet function.

What are the storage conditions for Dasatinib?

Store at 25°C. Store it in an airtight container and keep away from children.




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