• Cyclizine is an antihistamine drug used for the treatment of nausea and vomiting due to motion sickness, and due to drugs given in the post-operative period.
Cyclizine is a histamine H1 inhibitor prescribed for adults and children 6 years and above for the treatment of nausea and vomiting caused due to
• Motion sickness
• Drugs like narcotic analgesics and by general anaesthetics given in the post-operative period
• Radiotherapy, especially for breast cancer
• Menière's disease and other forms of vestibular disturbance (rarely)
Cyclizine was discovered in 1947. It is on the World Health Organization's List of Essential Medicines. Cyclizine also exerts a central anticholinergic (antimuscarinic) action.
Cyclizine is contraindicated
• If the patient is allergic to the drug or to any of the excipients in the drug.
• In patients with enlarged prostate, urinary retention and angle-closure glaucoma (due to its antimuscurinic effects).
• With alcohol, as the drug can increase the toxicity of alcohol.
The recommended dosage of cyclizine is 25 to 50 mg tablet
• For adults and for children over 12 years of age:
50 mg orally, which can be repeated if necessary up to three times a day.
• For children 6 years of age and above:
25 mg orally, which can be repeated if necessary up to three times a day.
Cyclizine should not be given to children less than 6 years old.
• Cyclizine should be administered orally every 4 to 6 hours.
• To prevent motion sickness it should be administered 30 min before traveling.
• Cyclizine should be used with caution in patients with glaucoma, urinary retention, obstructive disease of the gastrointestinal tract, hepatic disease, pheochromocytoma, hypertension, epilepsy and in males with possible prostatic hypertrophy.
• Cyclizine should be used with caution in patients with heart failure or heart attacks as it may decrease cardiac output while increasing heart rate and arterial pressure.
• Cyclizine should not be taken in porphyria (a group of disorders that is caused by malfunctioning in the iron producing chemical steps leading to nerve and skin disorders).
• Patients who have galactose intolerance or glucose-galactose malabsorption should not take cyclizine.
• Common: Drowsiness, dry mouth, constipation and blurred vision
• Skin effects: Allergic skin reactions, hives, drug rash, angioedema
• Nervous system effects: Somnolence, drowsiness, headache, dystonia, dyskinesia, extrapyramidal motor disturbances, tremors, convulsions, dizziness, decreased consciousness, depression, hallucinations
• Ophthalmological effects: Blurred or double vision
• Cardiac effects: Tachycardia, palpitations, arrhythmias, hypotension
• Gastrointestinal effects: Constipation, increased gastric reflux, nausea, vomiting, diarrhea, stomach pain, loss of appetite
• Others: Urinary retention, hypersensitivity reactions (bronchospasm, angioedema, anaphylaxis, and rashes)
• Use of cyclizine during pregnancy is not advised.
• Since cyclizine is excreted in human milk, it is best to check with your doctor on its use if you are breastfeeding.
• Cyclizine should not be taken with large amounts of alcohol.
• Patients should consult a doctor if feeling tired or weak and not able to urinate.
• Cyclizine may increase the effects of alcohol and central nervous system depressants like hypnotics and barbiturates.
• Cyclizine Hydrochloride increases the hemodynamic benefits of opioid analgesics and particularly increases the drowsiness normally caused by pethidine.
• Cyclizine may increase the side-effects of other anticholinergic drugs, and have an additive antimuscarinic action if given with other antimuscarinic drugs, such as atropine and some antidepressants (both tricyclics and MAOIs).
• Should be stored below 25°C.
• Keep out reach of children.
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