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Azathioprine - Indications, Dosage, Side Effects and Precautions

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Information about Azathioprine

Generic Name : Azathioprine
Latest prescription information about Azathioprine. Learn its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y45.4 | Therapeutic Classification : Antirheumatics
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Trade Names/Brand Names of Azathioprine

India : 

International : 

Azasan and Imuran
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Why is Azathioprine Prescribed? (Indications)

This medication is an immunosuppressant, prescribed for prevention of rejection kidney transplantation. It is also used for rheumatoid arthritis and autoimmune diseases. 
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When should Azathioprine not be taken? (Contraindications)

Contraindicated in patients with known hypersensitivity, previous treatment with alkylating agents, pregnancy and breastfeeding.

What is the dosage of Azathioprine?

Adult: PO- Rheumatoid arthritis Initial: 1 mg/kg/day for 6-8 wk. May adjust dose gradually to 2.5 mg/kg/day if needed.
Prevention of rejection in organ and tissue transplantation -1-5 mg/kg/day.
Auto-immune diseases -1-3 mg/kg/day.
IV -Renal homotransplantation- Usual initial: 3-5 mg/kg/day beginning at the time of transplantation. Maintenance: 1-3 mg/kg/day.

How should Azathioprine be taken?

It comes as a tablet to take by mouth, with food.

What are the warnings and precautions for Azathioprine?

• Caution should be exercised in patients with history of kidney or liver problems, gout, any infection, anemia, bone marrow depression, any allergy, who are taking other medications and children.

Avoid contact with people with infections.

It may reduce platelet counts; avoid injury or bruising.

Patient may experience severe nausea and vomiting; if it so consult with your doctor.

Patient may develop with increased risk of cancer; if you notice any unusual growth or tumor consult with your doctor immediately.

What are the side effects of Azathioprine?

   Blood : Decreased white blood cells and platelets.
   Gastrointestinal : Nausea, vomiting, diarrhea and abdominal pain.
   Miscellaneous : Rash, hair loss, fever, joint pain, diarrhea, negative nitrogen balance and reversible interstitial lung inflammation.

What are the other precautions for Azathioprine?

Monitor complete blood counts, liver function, and TPMT enzyme activity, while taking this medication.
Avoid excess dosage.

What are the storage conditions for Azathioprine?

Store it at room temperature and in an airtight container, keep away from children.

Schedule : H
Prescription drugs - Drugs to be sold only under the prescription of a Registered Medical Practitioner.



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