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Asenapine - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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Information about Asenapine

Generic Name : Asenapine
Pronunciation : a-SEN-a-peen
Latest prescription information about Asenapine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y49.5 | Therapeutic Classification : Psychotherapeutics
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Trade Names/Brand Names of Asenapine

India : 

International : 

Saphris
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Why is Asenapine Prescribed? (Indications)

This medication is an atypical antipsychotic agent, prescribed for schizophrenia and acute mania with bipolar disorder. It changes the activity of certain natural substances in the brain.
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When should Asenapine not be taken? (Contraindications)

Contraindicated in patients with severe liver problems, heart diseases, who are taking antiarrhythmic, antipsychotic, phenothiazine, quinolone drugs and hypersensitivity.

What is the dosage of Asenapine?

Sublingual- The recommended starting and target dose is 5 mg given twice daily.

How should Asenapine be taken?

It comes as a tablet to be placed under the tongue, with or without food.

What are the warnings and precautions for Asenapine?

• Caution should be exercised in patients with history of high blood pressure, cancer, Alzheimer disease, dementia, Parkinson disease, or esophagus problems, low blood volume, alcoholism, heart, liver, and kidney diseases, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.

It may cause drowsiness, dizziness, or lightheadedness, do not drive a car or operate machinery and get up slowly from bed while taking this medication.

Avoid alcohol consumption.

Avoid abrupt withdrawal; withdraw gradually.

Monitor complete blood cell counts, electrolyte levels, or fasting blood sugar levels regularly while taking this medication.

Patient may develop with increased risk of neuroleptic malignant syndrome (NMS) with the following symptoms: fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. If it is so consult with your doctor.

Avoid contact with people who have infections.

Drink adequate fluid; otherwise it may lead to dehydration.

What are the side effects of Asenapine?

   Most Common : Brain disorder, movement disorder, weight increased and drowsiness.
   Gastrointestinal : Constipation, dry mouth, motionless, increased saliva, stomach discomfort and vomiting.
   General : Fatigue and irritability.
   Metabolic : Increased appetite.
   Central Nervous system : Weakness, dizziness and sleeplessness.
   Heart : High blood pressure.

What are the other precautions for Asenapine?

Avoid excess dosage.
It may affect blood sugar level; monitor sugar level regularly while taking this medication.

What are the storage conditions for Asenapine?

Store it at room temperature (25C).



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