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Artemether and Lumefantrine - Indications, Dosage, Side Effects and Precautions

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Information about Artemether and Lumefantrine

Generic Name : Artemether and Lumefantrine
Pronunciation : ar-TEM-e-ther- LOO-me-FAN-treen
Latest prescription information about Artemether and Lumefantrine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y41.2 | Therapeutic Classification : Anti- Malarials
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Trade Names/Brand Names of Artemether and Lumefantrine

India- Abha-Lm, Adither Pl, Alither, Alither Forte, Anther, Arh-L, Arh-L Forte, Arlufe, Arsumet-L, Arte Plus, Artilum, Artivil Pl, Arumaria, A-Teem, Biofalcy-L, Coartrin, Combither, Duther, Epither , Falcimax P, Falcirid, Falcized-L, Falcydol, Go-Malra, Larither, Lphentin, Lumeart, Lumecap-A , Lumefal, Lumerax, Lumerax Syp, Lumether, Malatrit-E, Malither, Methicap, Nortee, Paluther, Rapither, R-Cure, Reonate-L, Rmther, Siothec-Lf, Sviz-Lf, Sviz-Lfd, Vixinate, Xeremal-Al, Zemal, Zemal Forte, Zemal Syr, Zensumet-L, Zuther.
International- Coartem.
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Why is Artemether and Lumefantrine Prescribed? (Indications)

This medication is an antimalarial agent, prescribed for malaria. 
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When should Artemether and Lumefantrine not be taken? (Contraindications)

It should not be co-administered with CYP3A4 inducers and patients with known hypersensitivity.

What is the dosage of Artemether and Lumefantrine?

Adult: PO- A 3-day treatment schedule with a total of 6 doses is recommended for adult patients with a bodyweight of 35 kg and above: Four tablets as a single initial dose, 4 tablets again after 8 hours and then 4 tablets twice daily (morning and evening) for the following two days (total course of 24 tablets). patients weighing less than 35 kg, should follow pediatric dosage.
Pediatric: Po- A 3-day treatment schedule with a total of 6 doses is recommended: 5 kg to less than 15 kg bodyweight: One tablet as an initial dose, 1 tablet again after 8 hours and then 1 tablet twice daily (morning and evening) for the following two days (total course of 6 tablets).
15 kg to less than 25 kg bodyweight: Two tablets as an initial dose, 2 tablets again after 8 hours and then 2 tablets twice daily (morning and evening) for the following two days (total course of 12 tablets).
25 kg to less than 35 kg bodyweight: Three tablets as an initial dose, 3 tablets again after 8 hours and then 3 tablets twice daily (morning and evening) for the following two days (total course of 18 tablets).
35 kg bodyweight and above: Four tablets as a single initial dose, 4 tablets again after 8 hours and then 4 tablets twice daily (morning and evening) for the following two days (total course of 24 tablets).

How should Artemether and Lumefantrine be taken?

It comes as a tablet and capsule to take by mouth, with food.

What are the warnings and precautions for Artemether and Lumefantrine?

• Caution needed for patients with history of heart, liver or kidney disease, mental illness, electrolyte imbalance, any allergy, who are taking other medications, during pregnancy and breastfeeding.

Avoid concomitant use of drugs known to prolong QT interval.

It may cause dizziness, do not drive a car or operate machinery while taking this medication.

Do not eat grapefruit or drink grapefruit juice while taking this medication.

What are the side effects of Artemether and Lumefantrine?

   Central Nervous System : Dizziness, fatigue, headache, trouble in sleeping, tiredness and weakness.
   Gastrointestinal : Diarrhea, loss of appetite, nausea, vomiting and stomach pain.
   Miscellaneous : Cough, joint and muscle pain and stiffness.

What are the other precautions for Artemether and Lumefantrine?

Avoid excess dosage.

What are the storage conditions for Artemether and Lumefantrine?

Store it at room temperature (25C).



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