This medication is a phenothiazine and tricyclic antidepressant combination, prescribed for anxiety and depression. Serotonin and noradrenaline reabsorption prevent by Amitriptyline where as Perphenazine blocks a variety of receptors in the brain
Contraindicated in patients with brain damage, blood disorders, liver damage, recent heart attack, blood disorder, who are taking depressants, who have taken monoamine oxidase inhibitor (MAOI) within last 14 days and hypersensitivity.
Adults - PO- Initially, usual dose is 2 to 4 mg perphenazine with 10 to 50 mg amitriptyline 3 to 4 times daily.
It comes as a tablet to take by mouth, with or without food.
• Caution should be exercised in patients with history of breast cancer, seizures, asthma or other breathing problems, trouble in urinating, alcohol abuse, depression, suicidal thoughts, lung infection, heart disease, Reye syndrome, Parkinson disease, increased eye pressure, high/low blood pressure, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
• It may cause drowsiness, dizziness or fainting, do not drive a car or operate machinery while taking this medication.
• Avoid alcohol consumption.
• Avoid exposure to sunlight; otherwise it may cause sunburn.
• It may cause heatstroke, protect from hot weather.
• This medication may develop increased risk of suicidal thoughts in children and teenagers; watch them carefully.
• Patient may develop with increased risk of neuroleptic malignant syndrome (NMS) with the following symptoms: fever, muscle tightness, confusion, abnormal thinking, fast or irregular heartbeat; and sweating. If it so consult with your doctor.
• Etrafon should not be discontinued suddenly. Dosage should be tapered gradually, especially following long-term treatment, to minimize withdrawal symptoms.
• When a medication containing perphenazine is taken for a long time, patients are advised to take a riboflavin (vitamin B2) supplement.
• Heart :
High/low blood pressure, slow/fast heart rate, fainting, heart arrest, poor blood circulation, abnormal heart rhythm, lightheadedness, faintness, dizziness, EKG changes and palpitations.
• Central Nervous System : Sedation, movement disorder, restlessness, rigidity, drowsiness, headache, weakness, anxiety, agitation, mania, exacerbation of psychosis, dizziness, tremor, fatigue, slurring of speech, sleeplessness, vertigo, seizures, abnormalities of CSF proteins, excitement, catatonic-like states, lethargy, hyperactivity and abnormal dreams.
• Skin : Photosensitivity reaction, pigmentation, dry skin, inflammation, hives, rash, skin disorder, pimples and itching.
• Eye and ENT : Increased eye pressure, photophobia, nose inflammation, inflammation of pharynx, ringing in the ear, blurred vision, nasal congestion, and dilatation of pupil.
• Gastrointestinal : Indigestion, intestinal obstruction, constipation, nausea, vomiting, loss of appetite, diarrhea, peculiar taste, dry mouth or throat.
• Genitourinary : Urinary retention, impotence, sexual dysfunction, menstrual irregularities and night time urination.
• Blood : Abnormal decrease in white blood cells, eosinophilia, anemia, bruising and decrease in platelets.
• Liver : Jaundice.
• Metabolic : Increase or decrease in blood sugar.
• Respiratory : Asthma, difficulty in breathing and cough.
• Miscellaneous : Increased appetite, weight and thirst, breast enlargement in males and milk secretion in women.
Patient may develop with involuntary muscle movements; if it so consult with your doctor immediately.
Store it at room temperature, and in an airtight container. Keep away from children. Protect unit-dose packages from excessive moisture.
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