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Allopurinol - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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Information about Allopurinol

Generic Name : Allopurinol
Pronunciation : (al oh pure'i nole)
Latest prescription information about Allopurinol. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Gout Therapy

Trade Names/Brand Names of Allopurinol


Why is Allopurinol Prescribed? (Indications)

Allopurinol is prescribed to treat gouty arthritis and prevent specific kidney stones by reducing high uric acid levels in the blood.

This medication is a xanthine oxidase inhibitor, recommended for treating the increased uric acid levels caused by cancer drugs.  

When should Allopurinol not be taken? (Contraindications)


What is the dosage of Allopurinol?

Adult: PO- Gout and Hyperuricaemia- Initial: 100 mg/day, may adjust dose according to response. Max: 800 mg/day.
Prevention of hyperuricaemia associated with chemotherapy treatment or enzyme disorders- 600-800 mg/day, starting 2-3 days before cancer treatment.
IV- Gout and Hyperuricaemia: As Na: 200-400 mg/m2/day. Max: 600 mg/day.

How should Allopurinol be taken?

It comes as a tablet to take by mouth, with food.

What are the warnings and precautions for Allopurinol?

• Caution should be exercised in patients with history of kidney or liver diseases, heart problems, bone marrow problems, high blood pressure, diabetes, who are taking other medication, any allergy, children, during pregnancy and breastfeeding.

It may cause drowsiness, do not drive a car or operate machinery while taking this medication.

Monitor kidney and liver function regularly while taking this medication.

What are the side effects of Allopurinol?

   Gastrointestinal : Diarrhea, nausea and increased level of liver enzymes.
   Metabolic : Acute attacks of gout.
   Skin : Rash.

What are the other precautions for Allopurinol?

Avoid excess dosage.
Follow the diet and exercise program as directed by your physician.

What are the storage conditions for Allopurinol?

Store it at controlled room temperature (15 to 25C) and in an airtight container.

Schedule : H
Prescription drugs - Drugs to be sold only under the prescription of a Registered Medical Practitioner.
Last Updated : July 2018

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Prashant_P, India

I have high uric acid[=7.7]. I have pain below heel in both legs. I have taken Zyloric for 2 months and uric acid is reduced from 9 to 7.7. But no improvement in heel pain. Please guide.

raju.com, Australia

I an 70 year old. I have been taking one tablet of Zyloric for the last more than 10 years. My uric acid is up to 5. I have no other symptoms. Now for the last two months I have developed acute pain in my back radiating to calf muscles [left side]. My MRI report is normal excepting for age related changes. I am feeling better with medication. I want to reduce the intake of Zyloric now to alternate days. Should I do it.

Ashish1274, India

I have problem of high uric acid since last three years with pain on right foot toe. the pain is unbearable. it subsides when i take zyloric 100.but after 3 month or so the uric acid level increases again with pain. Kindly help me to get over the problem comletely. My Blood sugar level keeps little high,and i have modified my diet to exclude red meat,sea food,Alcohol in very limited quantity, palak, tomato, pulses etc

nary123, India

Sir, I have problem of high uric acid since last three years with pain on right foot toe. the pain is unbearable. it subsides when i take zyloric 100.but after six month or so the uric acid level increses again with pain. Kindly help me to getover the problem comletely.my Blood sugar level is normal,and i have modified my diet to exclude red meat,sea food,Alcohol in very limited quantity, palak, tomato, pulses etc.

sahmad2003, Pakistan

It is very effective for kidney stone as well as crystall.but i have problem after taking the tab.zyloric 100mg gaining weigh persistently from last one year or so.its side also to hold the water inside the body??????????
Dr Syed Pakistan

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