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Aliskiren and hydrochlorothiazide - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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Information about Aliskiren and hydrochlorothiazide

Generic Name : Aliskiren and hydrochlorothiazide
Pronunciation : a-lis-KYE-ren/HYE-droe-KLOR-oh-THYE-a-zide
Latest prescription information about Aliskiren and hydrochlorothiazide. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y52.5 | Therapeutic Classification : Anti- Hypertensives
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Trade Names/Brand Names of Aliskiren and hydrochlorothiazide

International- Tekturna HCT.
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Why is Aliskiren and hydrochlorothiazide Prescribed? (Indications)

Aliskiren and hydrochlorothiazide combination helps to reduce the high blood pressure or hypertension that reduces the workload on the heart and the blood vessels. It also reduces the fluid accumulation by increasing the urine flow.

This combination medication is a direct renin inhibitor and a thiazide diuretic works by decreasing the substances in the body that narrow blood vessels and raise blood pressure.  It

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When should Aliskiren and hydrochlorothiazide not be taken? (Contraindications)

Contraindicated in patients with anuria (absence of urination), severe kidney problems, and hypersensitivity.
Do not use aliskiren with angiotensin receptor blockers (ARBs) and the angiotensin converting enzyme inhibitors (ACEIs)in patients with diabetes.

What is the dosage of Aliskiren and hydrochlorothiazide?

Adult- Tablet- The recommended dose is 150/12.5 mg once daily, 150/25 mg or 300/12.5 mg, and 300/25 mg.

How should Aliskiren and hydrochlorothiazide be taken?

It comes as a tablet to take by mouth, with or without food.

What are the warnings and precautions for Aliskiren and hydrochlorothiazide?

• Caution should be exercised in patients with history of gout, lupus, sugar, asthma, heart, kidney, liver problems, kidney stones, thyroid problems, high blood cholesterol, receiving dialysis treatment, dehydration, who are in low-salt diet, blood electrolyte problems, severe allergy, who are taking other medications, during pregnancy and breastfeeding.

It may cause dizziness, lightheadedness, or fainting, do not drive a car or operate machinery and get up slowly from bed while taking this medication.

Avoid alcohol consumption.

Patient may develop with serious side effect called angioedema with the following symptoms: swelling the hands, face, neck, etc; breathing trouble, and shock. If it is so consult with your doctor.

Avoid exposure to sunlight; otherwise it may cause sunburn.

It may affect sugar level; monitor blood sugar level regularly while taking this medication.

Monitor blood pressure, blood electrolyte levels, and kidney function regularly while taking this medication.

What are the side effects of Aliskiren and hydrochlorothiazide?

   Body As A Whole : Weakness.
   Gastrointestinal : Inflammation of pancreas, jaundice, cramping and gastric irritation.
   Blood : Anemia, decrease in white blood cells and platelets.
   Hypersensitivity : Bruising, sensitivity to light, hives, tissue death, fever, respiratory distress, lung swelling/inflammation and shock.
   Metabolic : Increased level sugar.
   Musculoskeletal : Muscle spasm.
   Central Nervous System : Restlessness.
   Genitourinary : Kidney failure, kidney impairment and kidney inflammation.
   Skin : Skin inflammation and skin death.
   Eye and ENT : Blurred vision.

What are the other precautions for Aliskiren and hydrochlorothiazide?

Avoid excess dosage.

What are the storage conditions for Aliskiren and hydrochlorothiazide?

Store it at room temperature (25C).

Last Updated : Jul 2018



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