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Alemtuzumab - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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Information about Alemtuzumab

Generic Name : Alemtuzumab
Pronunciation :  AL-em-TOOZ-oo-mab
Latest prescription information about Alemtuzumab. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y43.3 | Therapeutic Classification : Chemotherapy
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Trade Names/Brand Names of Alemtuzumab

International- Campath.
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Why is Alemtuzumab Prescribed? (Indications)

Alemtuzumab is a cancer-treating drug used for treating certain cancers of bone marrow and blood cancers such as chronic lymphocytic leukemia (CLL) and lymphoma. It is a monoclonal antibody used to treat multiple sclerosis.

 Alemtuzumab works by activating the immune system and destroys cancer cells.
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When should Alemtuzumab not be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Alemtuzumab?

IV- With Pre-medication- IV infusion over 2 hours-
Day 1: 3mg
Day 2: 10mg
Day 3: 30mg.

How should Alemtuzumab be taken?

It comes as a solution for injection to be administered by a healthcare provider into the vein.

What are the warnings and precautions for Alemtuzumab?

• Caution should be exercised in patients with history of shingles or chickenpox, high blood pressure, heart disease, or blood vessel problems, severe infection, poor immunity, bone marrow depression, blood transfusion, any allergy, who are taking other medications, children, during pregnancy and breastfeeding.

It may cause drowsiness or dizziness, do not drive a car or operate machinery while taking this medication.

It may reduce platelet counts; avoid injury or bruising.

Avoid live vaccination while taking this medication.

Monitor complete blood counts regularly while taking this medication.

What are the side effects of Alemtuzumab?

   Blood and Lymphatic : Abnormal decrease in white blood cells, platelets and anemia.
   General : Fever, chills and infections.
   Skin : Hives, rash and redness.
   Heart : Low blood pressure, high blood pressure and fast heart rate.
   Central Nervous System : Headache, tremor, sleeplessness and anxiety.
   Respiratory : Difficulty in breathing.
   Gastrointestinal : Diarrhea.

What are the other precautions for Alemtuzumab?

Avoid excess dosage.

What are the storage conditions for Alemtuzumab?

Store it at room temperature (15-30C) or refrigerate (2-8C). Protect from light.
Last Updated : Jul 2018



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