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Alefacept - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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Information about Alefacept

Generic Name : Alefacept
Pronunciation : ah-LEE-fah-sept
Latest prescription information about Alefacept. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y43.4 | Therapeutic Classification : Immunosuppressants
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Trade Names/Brand Names of Alefacept

International- Amevive.
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Why is Alefacept Prescribed? (Indications)

Alefacept is a genetically modified immunosuppressive drug prescribed for treating moderate to severe chronic plaque psoriasis in adult patients who are candidates for phototherapy or systemic therapy.

 It works by stopping the action of certain cells in the body that cause the symptoms of psoriasis.
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When should Alefacept not be taken? (Contraindications)

Contraindicated in patients with HIV, and hypersensitivity.

What is the dosage of Alefacept?

The recommended dose is 15 mg given once weekly as an intramuscular injection.

How should Alefacept be taken?

It comes as a solution to be administered by a healthcare provider into the large muscle.

What are the warnings and precautions for Alefacept?

• Caution should be exercised in patients with history of cancer, recurrent infection, who are taking radiation therapy, any allergy, who are taking other medications, during pregnancy and breastfeeding.

It may cause dizziness, do not drive a car or operate machinery while taking this medication.

It should not be used in children.

Avoid live vaccination while taking this medication.

What are the side effects of Alefacept?

   Serious Effects : Malignancy and abnormal decrease in lymphocytes.
   Most Common : Dizziness, increased cough, muscle pain, nausea, swelling at the injection site and sore throat.
   Miscellaneous : Itching, chills, cough, and accidental injury.

What are the other precautions for Alefacept?

Avoid excess dosage.

What are the storage conditions for Alefacept?

Store it in refrigerator (2-8C).
Last Updated : Jul 2018



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