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Acetaminophen and Propoxyphene - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team on Sep 20, 2013
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Information about Acetaminophen and Propoxyphene

Generic Name : Acetaminophen and Propoxyphene
Pronunciation : (a set a mee' noe fen) (proe pox i feen)
Latest prescription information about Acetaminophen and Propoxyphene. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y45.8 | Therapeutic Classification : Analgesics

Trade Names/Brand Names of Acetaminophen and Propoxyphene

India- Centrivon, Corbutyl, Dexovan, Parvon, Parvon-N, Proxyvon, Sudinol, Walageric, Wygesic.
International- Endocet, Darvocet-N 100, Darvocet A500, Dolene AP, Magnacet, Propacet, Narvox, Percocet, Perloxx, Primalev, Roxicet, Roxilox, Tylox,Trycet and Xolox.

Withdrawn from US market.

Why is Acetaminophen and Propoxyphene Prescribed? (Indications)

Acetaminophen or paracetamol helps to treat fever, reduce mild to moderate pain and propoxyphene is a narcotic (sleep-inducing) analgesic prescribed for treating moderate to severe pain.

Propoxyphene is a habit-forming drug and this combination is used only when it is required.  

When should Acetaminophen and Propoxyphene not be taken? (Contraindications)

Contraindicated in patients with diarrhea, food poisoning, who are taking sodium oxybate (GHB) and hypersensitivity.

What is the dosage of Acetaminophen and Propoxyphene?

The recommended adult dose is 1-2 tablets every 4 hours as needed for relief of pain. Do not exceed six 100/650 mg tablets or twelve 50/325 mg tablets in a 24-hour period. Other available dosages are propoxyphene/acetaminophen 65/650, 100/325 and 100/500 mg.

How should Acetaminophen and Propoxyphene be taken?

It comes as a tablet to take by mouth, with or without food.

What are the warnings and precautions for Acetaminophen and Propoxyphene?

• Caution should be exercised in patients with history of depression, mental or mood problems, head injury, brain disorders, increased pressure in the brain, seizures, suicidal thoughts or actions, stomach problems, any allergy, who are taking other medications, during pregnancy and breastfeeding.

It may cause drowsiness, do not drive a car or operate machinery while taking this medication.

Avoid long-term use of this drug.

Avoid excess dosage.

Avoid smoking while taking this medication. Smoking can decrease the drug effectiveness.

What are the side effects of Acetaminophen and Propoxyphene?

   Nervous system : Dizziness, light-headedness, drowsiness, sedation, confusion, mood changes, seizures and hallucinations.
   Gastrointestinal : Nausea, stomach upset, stomach pain, gastrointestinal bleeding, loss of appetite, vomiting and constipation.
   Heart : Palpitations, chest pain, fast or slow heart rate, decreased blood pressure, feeling like you might pass out, cardiac/respiratory arrest, congestive arrest, congestive heart failure (CHF), and myocardial infarction (MI).
   Eye : Blurred vision and eye swelling.
  Skin: Rash, itching.
  Miscellaneous: Dry mouth, weakness, itching, liver dysfunction and dark urine.

What are the other precautions for Acetaminophen and Propoxyphene?

Avoid alcohol consumption.
Propoxyphene may be habit-forming and should be used only by the prescribed person. Should never share this medication with another person, especially someone with a history of drug abuse or addiction.
Do not use this medication if the patient is on sodium oxybate.

What are the storage conditions for Acetaminophen and Propoxyphene?

Store it at room temperature (20 to 25C), and in airtight container. Keep away from children.
Last Updated : Jul 2018

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Bitter17, United States

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gemsonline12, India

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