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Acetaminophen and Oxycodone - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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Information about Acetaminophen and Oxycodone

Generic Name : Acetaminophen and Oxycodone
Pronunciation : (a set a mee' noe fen) (ox i koe' done)
Latest prescription information about Acetaminophen and Oxycodone. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y45.8 | Therapeutic Classification : Analgesics

Trade Names/Brand Names of Acetaminophen and Oxycodone

International- Percocet, Roxicet, Tylox, Oxycet, Roxilox.

Why is Acetaminophen and Oxycodone Prescribed? (Indications)

Acetaminophen and oxycodone is a combination of pain-relieving medications including non-opioid and narcotic or sleep-inducing drugs help to relieve moderate to severe pain.

Acetaminophen or paracetamol increase the pain-relieving effects of oxycodone. 


When should Acetaminophen and Oxycodone not be taken? (Contraindications)

Contraindicated in patients with significant respiratory depression, intestinal obstruction and hypersensitivity.

What is the dosage of Acetaminophen and Oxycodone?

The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams. The available dosages are oxycodone/acetaminophen 2.5/325, 7.5/325, 7.5/500, 10/325 and 10 /650 mg.

How should Acetaminophen and Oxycodone be taken?

It comes as a tablet, capsule and solution to take by mouth, with or without food.

What are the warnings and precautions for Acetaminophen and Oxycodone?

• Caution should be exercised in patients with history of liver or kidney diseases, heart problems, lung disease, seizure disorders, serious head injury or brain diseases, spinal problems, underactive thyroid, adrenal gland problems, breathing problems, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.

It may cause dizziness, lightheadedness, blurred vision or drowsiness, do not drive a car or operate machinery and get up slowly from bed while taking this medication.

Avoid alcohol consumption.

It may lead to constipation; take proper diet, drink adequate water and avoid antidiarrheals while on this medication.

What are the side effects of Acetaminophen and Oxycodone?

   Serious : Respiratory depression, difficulty in breathing, respiratory arrest, circulatory depression, low blood pressure and shock.
   Body as a Whole : Severe allergic reactions, uneasiness, weakness, fatigue, chest pain, fever, chills, thirst, headache and increased sweating.
  Heart : High blood pressure, fast/slow heart rate and palpitations.
   Central Nervous System : Lack of consciousness, tremor, tingling, drowsiness, seizures, epilepsy, anxiety, mental impairment, agitation, swelling of the brain, confusion, dizziness, sleeplessness, nervousness, hallucinations, depression, suicidal thoughts and drug abuse.
   Gastrointestinal : Indigestion, taste disturbances, abdominal pain, enlarged abdomen, increased sweating, diarrhea, dry mouth, flatulence, gastrointestinal disorders, nausea, vomiting, inflammation of pancreas, intestinal obstruction and constipation.
   Liver : Liver failure and jaundice.
   Eye and ENT : Hearing loss, ringing in the ear, visual disturbances and redness of eye.
   Blood : Decreased platelet count.
   Metabolic : Decreased/increased sugar level in blood, acidity, alkalosis and dehydration.
   Musculoskeletal : Muscle pain and weakness.
   Respiratory : Asthma, lung swelling, bronchospasm, respiratory arrest, respiratory depression, pulmonary edema, laryngeal edema and shallow/fast breathing.
   Skin and Appendages : Redness, rash, flushing and hives.
   Genitourinary : Liver inflammation, papillary necrosis, protein in urine, kidney insufficiency, kidney failure and urinary retention.

What are the other precautions for Acetaminophen and Oxycodone?

If condition worsens consult with your doctor.
Avoid excess dosage.

What are the storage conditions for Acetaminophen and Oxycodone?

Store it at room temperature (20 to 25C) and in an airtight light- resistant container. Keep away from children.

Last Updated : Jul 2018

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